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DNA replicase

an aspect of EC 2.7.7.7; mouse enzyme has both DNA polymerase and DNA primase activity

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Nucleotidyltransferases: 29
        DNA Nucleotidyltransferases: 4
        DNA-Directed DNA Polymerase: 1706
        DNA replicase: 6

Experts

1.	Bosse, Tjalling: 1 article (07/2015)
2.	Church, David N: 1 article (07/2015)
3.	Creutzberg, Carien L: 1 article (07/2015)
4.	Eggink, Florine A: 1 article (07/2015)
5.	Freeman-Mills, Luke: 1 article (07/2015)
6.	Klenerman, Paul: 1 article (07/2015)
7.	Marchi, Emanuele: 1 article (07/2015)
8.	Nijman, Hans W: 1 article (07/2015)
9.	Nout, Remi A: 1 article (07/2015)
10.	Osse, Elisabeth M: 1 article (07/2015)

Related Diseases

1.	Ascites 08/01/1988 - "The effect of a single-stranded DNA-binding protein (SSB-protein) form Ehrlich ascites tumour cells (EAT) on the activity of homologous purified DNA-polymerases alpha and beta, DNA-replicase, primase and DNA-polymerases from phage T4 and Bacillus stearothermophillus was studied. " 11/10/1983 - "The stimulating factor obtained from Ehrlich ascites cells has been found to stimulate both the activities of DNA primase and DNA polymerase in DNA replicase obtained from all the vertebrates examined, when unprimed single-stranded DNA was used as template, while the factor failed to stimulate both the activities of the enzyme of sea urchin embryos. " 01/01/1986 - "The purpose of this study was to determine firstly whether the isolated enzyme DNA polymerase alpha, which functions within the DNA replicase system, exhibits different sensitivity against the thiol-blocking agent 4-hydroxy-nonenal (HNE) when adult rat liver and the rapidly dividing Yoshida ascites hepatoma were used as enzyme sources and, secondly, whether the reaction catalysed by DNA polymerase is the most sensitive step of the DNA replicase system of native cells. "
2.	Endometrial Neoplasms (Endometrial Cancer) 07/15/2015 - "Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA replicase POLE. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1986 - "It was concluded that in the DNA replicase system of native liver and hepatoma cells another process different from the reaction catalysed by DNA polymerase alpha is more sensitive to HNE." 01/01/1986 - "The purpose of this study was to determine firstly whether the isolated enzyme DNA polymerase alpha, which functions within the DNA replicase system, exhibits different sensitivity against the thiol-blocking agent 4-hydroxy-nonenal (HNE) when adult rat liver and the rapidly dividing Yoshida ascites hepatoma were used as enzyme sources and, secondly, whether the reaction catalysed by DNA polymerase is the most sensitive step of the DNA replicase system of native cells. "
4.	Thymoma (Thymic Carcinoma) 01/01/1983 - "Detection of DNA replicase activity in rat thymoma cells."
5.	Starvation 06/02/1986 - "The experiments using either C3H2K cells, synchronized by serum starvation, or Ehrlich culture cells, arrested at the S phase by aphidicolin, showed DNA replicase to increase in cells in the S phase to at least six times that of the G0-phase cells but 7.3S polymerase to increase but slightly in this phase. "

Related Drugs and Biologics

1.	DNA-Directed DNA Polymerase (Polymerases, DNA)
2.	Enzymes
3.	Sulfhydryl Compounds (Thiols)
4.	Exonucleases (3' 5' Exonuclease)
5.	DNA Polymerase I (Klenow Fragment)
6.	DNA Primase (Primase)
7.	Aphidicolin
8.	Proteins (Proteins, Gene)
9.	Single-Stranded DNA (DNA, Single Stranded)
10.	DNA-Binding Proteins (DNA Binding Protein)