|1.||Assaraf, Yehuda G: 4 articles (04/2009 - 02/2003)|
|2.||Nilsson, Staffan: 4 articles (07/2008 - 12/2003)|
|3.||Wettergren, Yvonne: 4 articles (07/2008 - 12/2003)|
|4.||Gustavsson, Bengt: 4 articles (07/2008 - 12/2003)|
|5.||Odin, Elisabeth: 4 articles (07/2008 - 12/2003)|
|6.||Carlsson, Göran: 3 articles (07/2008 - 12/2003)|
|7.||Gangjee, Aleem: 3 articles (02/2008 - 05/2002)|
|8.||Leclerc, Guy J: 2 articles (12/2010 - 01/2006)|
|9.||Barredo, Julio C: 2 articles (12/2010 - 01/2006)|
|10.||Jansen, Gerrit: 2 articles (07/2008 - 02/2003)|
10/19/2000 - "Metabolite protection studies and folylpoly-gamma-glutamate synthetase studies suggest that the antitumor activity of 3a against the growth of tumor cells in culture is a result of dual inhibition of TS and DHFR. "
04/01/1999 - "Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. "
01/01/1995 - "Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity."
01/01/1992 - "For six patients, folylpolyglutamate synthetase was measured in the center of the tumor, in the transitional region from tumor to 'normal' tissue, and in the 'normal' tissue. "
08/01/1984 - "Folylpolyglutamate synthetase was measured in a series of mouse tissues and tumors. "
04/30/2009 - "Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia."
11/17/2000 - "Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues."
04/28/2000 - "Folylpolyglutamate synthetase (FPGS) activity in CCRF-CEM human leukemia cells was found in the cytosolic ( approximately 67% of total) and mitochondrial ( approximately 22%) fractions. "
08/01/1997 - "The major difference found between leukemia cells that accumulate long chain polyglutamates and those that do not were differences in Km values for the enzyme folylpolyglutamate synthetase. "
09/01/1990 - "NaHCO3 activated the folylpolyglutamate synthetase (FPGS) from rat liver and the human leukemia cell lines K562 and CCRF-CEM by 1.7- to 2.0-fold. "
|3.||Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/01/2015 - "Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia."
12/01/2010 - "Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia."
10/30/2005 - "Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells."
04/01/2014 - "This study was aimed to explore the relation between folylpolyglutamate synthetase (FPGS) rs10760502 polymorphism and prognosis and methotrexate (MTX)-related toxicities in pediatric B-cell acute lymphoblastic leukemia (B-ALL). "
06/15/1998 - "The effect of down-regulation of folylpoly-gamma-glutamate synthetase (FPGS) activity on intracellular reduced folate accumulation and cellular proliferation was examined, using an inducible antisense expression system in the human T-lymphoblastic leukemia cell line CCRF-CEM. "
|4.||Head and Neck Neoplasms (Head and Neck Cancer)
01/01/1992 - "The results of this study provide further support for the concept that putative differences in folylpolyglutamate synthetase activity between tumor tissue and normal tissue can be exploited to improve the effectiveness of antifolate-based chemotherapy in general, and in head and neck cancer in particular."
|5.||Colorectal Neoplasms (Colorectal Cancer)
07/01/2008 - "Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients. "
01/01/1999 - "Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors."
01/01/2005 - "Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients."
12/01/2003 - "Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102). "
|2.||Folic Acid (Vitamin M)
|4.||Folic Acid Antagonists
|5.||gamma-Glutamyl Hydrolase (Carboxypeptidase G2)
|7.||Reduced Folate Carrier Protein
|8.||Messenger RNA (mRNA)
|9.||Glutamic Acid (Glutamate)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)