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pantothenate kinase

RefSeq NM_023792 (Pank1, mouse), NM_153638 (PANK2, human); GenBank AF221546 (drosophila)
Also Known As:
ATP-pantothenate 4'-phosphotransferase; D-pantothenate kinase; NBIA1 protein, human; PANK1 protein, human; PANK1a protein, human; PANK1b protein, human; PANK2 protein, human; PANK3 protein, human; Pank1 protein, mouse; Pank1a protein, mouse; Pank1b protein, mouse; Pank3 protein, mouse; Pantothenic acid kinase; Rts protein, E coli; coaA protein, E coli; fbl protein, Drosophila; fumble protein, Drosophila; panK protein, E coli; pantothenate kinase 1, human; pantothenate kinase 1, mouse; pantothenate kinase 2 (Hallervorden-Spatz syndrome) protein, human; pantothenate kinase 3, human; pantothenate kinase 3, mouse
Networked: 63 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Hayflick, Susan J: 7 articles (08/2014 - 01/2003)
2. Jackowski, Suzanne: 4 articles (01/2015 - 03/2005)
3. Westaway, Shawn K: 4 articles (07/2005 - 01/2003)
4. Leonardi, Roberta: 3 articles (01/2015 - 03/2005)
5. Hayflick, S J: 3 articles (06/2007 - 08/2001)
6. Gitschier, J: 3 articles (06/2007 - 08/2001)
7. Zhang, Yong-Mei: 3 articles (01/2007 - 03/2005)
8. Rock, Charles O: 3 articles (01/2007 - 03/2005)
9. Gitschier, Jane: 3 articles (01/2005 - 01/2003)
10. Finazzi, Dario: 2 articles (01/2016 - 08/2010)

Related Diseases

1. Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease)
2. Tuberculosis (Tuberculoses)
3. Avian Malaria
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Dystonia (Limb Dystonia)
01/01/2015 - "The patient, initially suspected of idiopathic isolated dystonia, finally presented with pantothenate kinase 2-associated neurodegeneration phenotype and was a carrier of two PANK2 mutations. "
12/01/2003 - "Disease caused by mutations in the gene encoding pantothenate kinase 2 (PANK2) is characterized by dystonia and pigmentary retinopathy in children or speech and neuropsychiatric defects in adults, in concert with a specific pattern on MRI of the brain. "
02/01/2009 - "Pantothenate kinase-associated neurodegenerative disease (PKAN) is a secondary generalized dystonia associated with an accumulation of iron in the basal ganglia and increased motor cortex excitability. "
10/23/2006 - "Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase associated neurodegeneration (PKAN), an autosomal recessive (AR) disorder characterized by motor symptoms as such as dystonia or parkinsonism, mental retardation, retinitis pigmentosa and iron accumulation in the brain. "
11/01/2010 - "We cover dopa-responsive dystonia, Wilson's disease, Parkin-, PINK1-, and DJ-1-associated parkinsonism (PARK2, 6, and 7), x-linked dystonia-parkinsonism/Lubag (DYT3), rapid-onset dystonia-parkinsonism (DYT12) and DYT16 dystonia, the syndromes of Neurodegeneration with Brain Iron Accumulation (NBIA) including pantothenate kinase (PANK2)- and PLA2G6 (PARK14)-associated neurodegeneration, neuroferritinopathy, Kufor-Rakeb disease (PARK9) and the recently described SENDA syndrome; FBXO7-associated neurodegeneration (PARK15), autosomal-recessive spastic paraplegia with a thin corpus callosum (SPG11), and dystonia parkinsonism due to mutations in the SLC6A3 gene encoding the dopamine transporter. "

Related Drugs and Biologics

1. Coenzyme A (CoA)
2. Enzymes
3. Iron
4. Neurodegeneration with brain iron accumulation (NBIA)
5. Pantothenic Acid (Calcium Pantothenate)
6. Phospholipases A2 (Phospholipase A2)
7. Protein Isoforms (Isoforms)
8. Neuroferritinopathy
9. Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
10. Ligases

Related Therapies and Procedures

1. Deep Brain Stimulation
2. Anesthesia