tosylarginine methyl ester hydrolase (tamase)
protease from sea urchin (Arbacia punctulata) eggs; fertilization in the sea urchin is accompanied by the release of this protease from eggs into the surrounding seawater; enzyme uses TAME as substrate; used as a measure of trypsin-like activity; tryptase (formerly here) is mast cell tryptase (EC 3.4.21.59)
Also Known As:
tamase; N-tosyl-L-arginine methyl ester esterase; TAME esterase; TAME hydrolase; esterase A2; tamase-1
Networked: 39
relevant articles (2 outcomes,
3 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Sneezing
02/01/1992
- " After a single dose of azelastine, there was a significant reduction in sneezing (10 vs 2, P = 0.01) and in the median levels of recovered TAME-esterase activity (63.1 vs 17.5 c.p.m. " 01/01/1990
- " Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. " 12/01/1989
- " Compared with placebo, both antihistamines significantly reduced sneezing and the levels of recovered albumin and TAME esterase activity, suggesting that both reduced the expected increase in vascular permeability. " 01/01/1989
- " Sneezing, blockage, and secretions were associated with increased concentrations of TAME esterase (maximum 9000 cpm/ml), kinins (1.4 ng/ml), and albumin (0.3 g/l) in lavage fluid. " 12/01/1985
- " The immunized group had a diminished response as demonstrated by (a) the treated group required higher pollen doses to excite sneezing or mediator release; (b) significantly fewer subjects in the treated group released mediators at any dose (TAME-esterase [P = 0.005], PGD2 [P = 0.04]), and (c) the treated group released 3-5-fold less mediator (TAME-esterase [P = 0.01], and histamine [P = 0.02])."
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2. | Inflammation (Inflammations)
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3. | Anaphylaxis (Anaphylactic Shock)
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4. | Rhinorrhea
08/01/1995
- " Compared with baseline, cold dry air induced significant rhinorrhea and increased both secretion weights (9.6 +/- 1.3 vs. 28.1 +/- 6.5 mg; P = 0.01) and the levels of histamine (3.9 +/- 1.2 vs. 10.6 +/- 2.7 ng/ml; P = 0.02) and TAME esterase activity (3.1 +/- 0.8 vs. 7.0 +/- 2.0 counts.min-1.10(-3); P = 0.01). " 08/01/1992
- " Even with atropine, however, rhinorrhea and TAME-esterase activity were still significantly increased over the prechallenge baseline. " 08/01/1988
- " All 12 subjects showed an immediate response, whereas 8 had a LPR, as indicated by a recurrence of symptoms (rhinorrhea and congestion) hours later, accompanied by an increase in the levels of histamine and TAME-esterase activity. " 04/01/1991
- " Between-group analysis revealed that IT significantly reduced the levels of histamine, TAME-esterase activity, and kinins, as well as symptoms of rhinorrhea and congestion generated during the ER to nasal challenge. " 08/01/1992
- " Atropine significantly reduced rhinorrhea, the levels of histamine, and TAME-esterase activity as well as the osmolality of recovered lavage fluids, but had no effect on nasal congestion or albumin. "
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5. | Hypertension (High Blood Pressure)
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