|1.||Robertson, Larry W: 4 articles (10/2014 - 11/2010)|
|2.||Di Giulio, Richard T: 4 articles (05/2012 - 09/2002)|
|3.||National Toxicology Program: 4 articles (11/2006 - 01/2006)|
|4.||Vorrink, Sabine U: 3 articles (10/2014 - 01/2014)|
|5.||Domann, Frederick E: 3 articles (10/2014 - 01/2014)|
|6.||Ludewig, Gabriele: 3 articles (12/2012 - 11/2010)|
|7.||Hanneman, William H: 3 articles (05/2007 - 04/2004)|
|8.||Olivier, Alicia K: 2 articles (10/2014 - 12/2012)|
|9.||Ropstad, Erik: 2 articles (01/2014 - 01/2006)|
|10.||Bursian, Steven J: 2 articles (01/2013 - 03/2005)|
|1.||Communicable Diseases (Infectious Diseases)
04/01/2001 - "Furthermore, a morphometrically determined significant reduction in relative thymus size was noted in animals exposed to 50 mg PCB-126/kg. Although the functional implications for the immune system of this reduction need to be further investigated, an impact on the specific resistance against infectious diseases as observed in the field, e.g. "
|2.||Body Weight (Weight, Body)
12/08/2012 - "After one week, rats on each diet were exposed to 0, 1, or 5μmol/kg body weight PCB 126 by i.p. "
11/01/2011 - "PCB exposure caused dose-dependent increases in liver weight and at the highest PCB 126 dose decreases in whole body weight gains. "
08/01/2010 - "These results indicate that developmental exposure to a low, environmentally relevant dose of PCB 126 causes long-lasting hyperactivity in male rats, and a significant increase in body weight."
08/01/2010 - "Furthermore, an additional effect (increased body weight) was unmasked in adulthood in male rats exposed to PCB 126. "
04/01/2004 - "PCB 126 was applied orally at a dose of approximately 100 ng PCB 126 per g body weight. "
09/01/2008 - "These results are consistent with the results from cancer bioassays that demonstrated a synergistic effect between PCB 126 and PCB 153 on toxicity and tumor development. "
11/01/2003 - "We then compared the effects of the coplanar PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and the noncoplanar PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl) with effects of two model GJIC inhibitors, a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF). "
01/01/2006 - "PCB 126 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs. "
09/01/2006 - "TCDD, PeCDF, and PCB 126 were selected for study by the National Toxicology Program as part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs. "
03/01/2002 - "This study evaluates and quantifies the interactive hepatic tumor promoting effects of two PCBs, the Ah receptor agonist PCB 126 (3,3',4,4',5-pentachlorobiphenyl) and the constitutive androstane receptor (CAR) agonist PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl). "
|4.||Congenital Abnormalities (Deformity)
03/15/2007 - "Exposure to 0.25 ng/g PCB 126 elevated mortality (61% and 69%) and deformities (31% and 32%), three or more times higher than controls. "
12/01/2004 - "In agreement with previous studies, coexposure of embryos to PCB-126 with the AHR antagonist and CYP1A inhibitor alpha-naphthoflavone decreased frequency and severity of deformities compared with embryos exposed to PCB-126 alone. "
05/01/2012 - "Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos."
09/01/2002 - "There was a significant correlation between deformity occurrence and EROD induction in embryos dosed with PCB alone but not for embryos dosed with BaP alone, or a combination of BaP and PCB 126."
09/01/2002 - "The goal of this study was to assess the interactive effects of a polynuclear aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), and a co-planar halogenated aromatic hydrocarbon (HAH), 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on ethoxyresorufin-O-deethylase (EROD) activity and occurrence of deformities in Fundulus heteroclitus. "
03/26/2005 - "This study explored the hypothesis that the thymic atrophy produced by developmental exposure to PCB 126 is associated with an increase in apoptotic thymocytes at the end of incubation in chicken embryos. "
03/26/2005 - "The results of this experiment supported the hypothesis that the thymic atrophy produced by developmental exposure to PCB 126 in chicken embryos is associated with an increase in apoptotic thymocytes on embryonic d 20."
08/01/2006 - "These responses were also affected by administration of the mixture of PCB 126 and PCB 153 at the end of the 2-year study and were accompanied by additional nonneoplastic responses in numerous organs including atrophy of the adrenal cortex and cortical hyperplasia, severity of nephropathy, and incidences of pigmentation of the kidney. "
03/26/2005 - "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyl (PCB) 126 produce thymic atrophy and immunosuppression. "
08/01/1994 - "An estimated daily intake of 0.47 micrograms PCB 126/kg body weight/day caused thymic atrophy, a dramatic loss in hepatic retinoids, and a marked induction in CYP1A1 and CYP1A2 activities. "
|2.||Polychlorinated Biphenyls (PCBs)
|5.||Corn Oil (Oil, Corn)
|10.||Cytochrome P-450 CYP1A1 (CYP1A1)
|1.||Euthanasia (Mercy Killing)