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echinocystic acid

aglycone moiety of saponin chrysantellin

Also Known As:

(3 beta,16 alpha)-3,16-dihydroxyolean-12-en-28-oic acid

Networked: 20 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Oleanolic Acid: 547
        echinocystic acid: 20
      - Sapogenins: 26
        Oleanolic Acid: 547
        echinocystic acid: 20

Experts

1.	Joh, Eun-Ha: 3 articles (02/2014 - 08/2012)
2.	Kim, Dong-Hyun: 3 articles (02/2014 - 08/2012)
3.	Cao, Xiang: 2 articles (02/2021 - 10/2019)
4.	Chen, Beilei: 2 articles (02/2021 - 10/2019)
5.	Chen, Jian: 2 articles (02/2021 - 10/2019)
6.	Li, Wei: 2 articles (02/2021 - 10/2019)
7.	Song, Lilong: 2 articles (02/2021 - 10/2019)
8.	Wang, Sushan: 2 articles (02/2021 - 10/2019)
9.	Wang, Xinyue: 2 articles (02/2021 - 10/2019)
10.	Xu, Yun: 2 articles (02/2021 - 10/2019)

Related Diseases

1.	Hyperhomocysteinemia 11/01/2017 - "Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-κB and CYP1A1." 11/01/2017 - "The present study investigated the role of echinocystic acid (EA) on the expression of nuclear factor (NF)-κB and cytochrome P450 1A1 (CYP1A1), and aortic morphology, in a rat model of hyperhomocysteinemia (Hhcy). "
2.	Inflammation (Inflammations) 09/01/2022 - "Effects of Echinocystic Acid on Atopic Dermatitis and Allergic Inflammation of the Skin and Lungs." 12/28/2022 - "Echinocystic Acid Ameliorates Arthritis in SKG Mice by Suppressing Th17 Cell Differentiation and Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Inflammation." 01/01/2021 - "Echinocystic Acid Inhibits Inflammation and Exerts Neuroprotective Effects in MPTP-Induced Parkinson's Disease Model Mice." 02/01/2013 - "Lancemaside A and its metabolite, echinocystic acid, inhibited TNBS-induced colonic inflammation, including colon shortening, increased myeloperoxidase activity and pro-inflammatory cytokine expression, and NF-κB activation in mice. "
3.	Rheumatoid Arthritis 12/28/2022 - "Echinocystic Acid Ameliorates Arthritis in SKG Mice by Suppressing Th17 Cell Differentiation and Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Inflammation." 05/01/2009 - "Echinocystic acid (1), an echinocystic acid saponin, 2, and four of its ester saponins, 3-6, obtained from the active fraction of Impatiens pritzellii var. hupehensis, an traditional Chinese medicine for rheumatoid arthritis, were investigated for their effects on lipopolysaccharide (LPS)-induced interleukin (IL)-18 in human peripheral blood mononuclear cells. "
4.	Pneumonia (Pneumonitis) 08/01/2012 - "Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways." 08/01/2012 - "Echinocystic acid suppressed LPS-induced acute lung inflammation in mice, as well as the expression of pro-inflammatory cytokines, such as IL-1β and TNF-α, and their transcription factor, NF-κB. "
5.	Otitis 02/01/2014 - "Therefore, to understand whether echinocystic acid is effective against skin inflammatory diseases, we assessed its inhibitory effect against 12-O-tetra decanoylphorbol-13-acetate (TPA)-induced ear inflammation in mice. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	Triterpenes
3.	Oleanolic Acid
4.	Glucose (Dextrose)
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	Cholesterol
7.	eclalbasaponin I
8.	eclalbasaponin II
9.	Cytokines
10.	Plant Extracts

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)