2-oxindole (oxindole)

RN given refers to parent cpd; structure

Also Known As:

oxindole; 1,3-dihydro-2h-indol-2-one; 1,3-dihydroindol-2-one; 1h-indol-2-ol; 2-hydroxyindole; 2-indolinone; 2-oxindole perchlorate; 2h-indol-2-one, 1,3-dihydro-; diclofenac impurity E; indol-2(3h)-one; indol-2-ol; indoline-2-one

Networked: 89 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Oxindoles: 118
      - 2-oxindole: 89
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Oxindoles: 118
        2-oxindole: 89
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Oxindoles: 118
        2-oxindole: 89

Experts

1.	Furuta, Kyoji: 4 articles (01/2022 - 01/2020)
2.	Hirata, Yoko: 4 articles (01/2022 - 01/2020)
3.	Kamal, Ahmed: 4 articles (01/2018 - 12/2013)
4.	Oh-Hashi, Kentaro: 3 articles (01/2022 - 01/2020)
5.	Shaik, Anver Basha: 3 articles (01/2018 - 12/2013)
6.	Banerjee, Rajkumar: 3 articles (08/2017 - 04/2014)
7.	Pal, Abhishek: 3 articles (08/2017 - 04/2014)
8.	Li, Yong: 2 articles (05/2022 - 01/2018)
9.	Kamatari, Yuji O: 2 articles (01/2022 - 01/2022)
10.	Kamishina, Hiroaki: 2 articles (01/2022 - 01/2022)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2003 - "To study the antitumor mechanism of 3-substituted aryl oxindole (PH II-7) and determine its effects on cell cycle distribution of tumor cells. " 08/31/2023 - "According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4." 07/07/2017 - "The impact of the substituent at the 3-position of 2-oxindole core on the potency and selectivity against a panel of seven different cancer cell lines was examined. " 01/01/2017 - "A series of 2-oxindole derivatives were synthesized and evaluated for cytotoxic activity against different human and murine cancer cell lines and cancer chemopreventive activity. " 01/01/2016 - "In this review, the therapeutic applications of 2-indolinone derivatives for the treatment of cancer reported in international patents have been discussed. "
2.	Breast Neoplasms (Breast Cancer) 06/06/2017 - "Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule." 10/01/2019 - "In vitro EGFR inhibition assay is performed with the potent cytotoxic oxindole compounds which are previously proved for their cytotoxic activity against breast cancer (MCF7) and ovarian cancer (SKVO3) cell lines. " 12/01/2021 - "Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies." 01/01/2018 - "DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma." 08/31/2023 - "Most bis-oxindole and bis-spiro-triazole-oxindole compounds effectively inhibited the growth of MCF-7 (IC50 = 2.81-17.61 μM) and MDA-MB-231 (IC50 = 3.23-7.98 μM) breast cancer cell lines with low inhibitory activity against normal WI-38 cells. "
3.	Melanoma (Melanoma, Malignant) 08/22/2017 - "Cationic folate-mediated liposomal delivery of bis-arylidene oxindole induces efficient melanoma tumor regression." 10/05/2023 - "In the present study, the effects of 3-[3'-oxo-benzo[b]thiophen-2'-(Z)-ylidene]-1-(β-d-glucopyranosyl)-oxindole (KD87), a thia-analogous indirubin N-glycoside, on the viability and mitochondrial properties of melanoma (A375) and squamous cell carcinoma cells (A431) of the skin were investigated. " 10/01/2015 - "In recent years, a class of oxindole-copper and -zinc complex derivatives have been reported as compounds with efficient proapoptotic activity toward different tumor cells (e.g., neuroblastomas, melanomas, monocytes). " 01/01/2022 - "A series of 17 indolo/pyrroloazepinone-oxindole conjugates was synthesized and evaluated for their antiproliferative activity against a panel of selected human cancer cell lines including A549 (lung cancer), HCT116 (colon cancer), MCF7 (breast cancer), and SK-MEL-28 (melanoma). " 07/21/2021 - "A series of novel mono and bishydrazones each bearing a 2-oxindole moiety along with substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane, or diphenylamine fragments were synthesized, and their anticancer activities were tested by MTT assay against human melanoma A375 and colon adenocarcinoma HT-29 cell lines. "
4.	Hepatic Encephalopathy 01/01/1997 - "Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy?" 06/20/1998 - "Oxindole in pathogenesis of hepatic encephalopathy." 06/01/2010 - "Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy." 09/01/1999 - "The present findings are in line with the possibility that oxindole may be an additional L-tryptophan-related candidate in the pathogenesis of chronic hepatic encephalopathy." 09/01/1999 - "In the present investigation, we found that oxindole levels were significantly increased in the blood and brain of portacaval-shunted rats, an animal model of chronic hepatic encephalopathy, compared with sham-operated controls. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/05/2023 - "In the present study, the effects of 3-[3'-oxo-benzo[b]thiophen-2'-(Z)-ylidene]-1-(β-d-glucopyranosyl)-oxindole (KD87), a thia-analogous indirubin N-glycoside, on the viability and mitochondrial properties of melanoma (A375) and squamous cell carcinoma cells (A431) of the skin were investigated. " 05/09/2022 - "In the present study, we demonstrate cytotoxic activity of the thia-analogous indirubin N-glycosides KD87 (3-[3'-oxo-benzo[b]thiophen-2'-(Z)-ylidene]-1-(β-d-glucopyranosyl)-oxindole) and KD85 (3-[3'-oxo-benzo[b]thiophen-2'-(Z)-ylidene]-1-(β-d-mannopyranosyl)-oxindole) against melanoma and squamous cell carcinoma cells as well as lung cancer and glioblastoma cells. "

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6.	Glycosides
7.	indirubin
8.	Antineoplastic Agents (Antineoplastics)
9.	pyrazole
10.	indole

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)