HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
3,5-dimethyl-3'-isopropyl-L-thyronine
RN given refers to (L)-isomer
Also Known As:
3,5-dimethyl-3'-isopropyl-L-thyronine, (DL)-isomer; DIMIT; O-(4-hydroxy-3-(1-methylethyl)phenyl)-3,5- dimethyl-L-tyrosine
Networked:
10
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Thyroid Hormones: 10782
Thyronines: 89
3,5-dimethyl-3'-isopropyl-L-thyronine: 10
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Cyclic Amino Acids: 3
Aromatic Amino Acids: 467
Thyroxine: 10784
Thyronines: 89
3,5-dimethyl-3'-isopropyl-L-thyronine: 10
Related Diseases
1.
Hyperthyroidism
03/01/1986 - "
Hyperthyroidism induced by T4 (100 micrograms/d IP X 3 days), T3 (80 micrograms/d IP X 3 days) or DIMIT (45 micrograms/d IP X 3 days) significantly stimulated T4-to-rT3 conversion; DIMIT was the most potent agent.
"
01/01/1984 - "
DIMIT-induced hyperthyroidism was shown to affect the development of the fetal brain.
"
01/01/1987 - "
3,5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT)-induced fetal hyperthyroid rats showed a marked accumulation of intracellular tubulin content in the cerebral cortex, hypothalamus, and cerebellum at 1 day old.
"
01/01/1984 - "
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth.
"
2.
Body Weight (Weight, Body)
01/01/1983 - "
In experiment 2, rats 4 and 11 days old were injected for 4 continuous days with T3 (0.1 or 0.5 micrograms/g body weight) or a synthetic analog, DIMIT (at the same dose), with sacrifice on the 5th day.
"
05/15/1986 - "
Comparative effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2) on body weight gain and lipid metabolism in genetically obese Zucker rats.
"
01/01/1984 - "
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth.
"
05/15/1986 - "
3,5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2), two thyroid hormone analogs, have been tested in genetically obese Zucker rats and their lean littermates, in comparison with thyroxine (T4) and triiodothyronine (T3) for their thyromimetic activities on body weight gain and lipid levels in serum and liver.
"
3.
Hypothyroidism
10/01/1993 - "
This serious adverse effect became apparent at a DIMIT-dose that is not sufficient for a complete compensation of foetal hypothyroidism in utero.
"
06/01/1983 - "
Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on fetal hypothyroidism in primates.
"
06/01/1983 - "
We conclude that DIMIT administration to 131I-treated monkeys prevents clinical and biochemical hypothyroidism in the mother and prevents the major clinical manifestations of cretinism in the fetus.
"
06/01/1983 - "
In an effort to prevent both maternal and fetal hypothyroidism, we treated 131I-treated pregnant monkeys with 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), a thyroid hormone analog with structural changes which facilitate placental transfer.
"
4.
Congenital Hypothyroidism (Cretinism)
07/01/1982 - "
Treatment of ovine cretinism in utero with 3,5-dimethyl-3'-isopropyl-L-thyronine.
"
06/01/1983 - "
We conclude that DIMIT administration to 131I-treated monkeys prevents clinical and biochemical hypothyroidism in the mother and prevents the major clinical manifestations of cretinism in the fetus.
"
07/01/1982 - "
In contrast to DIMIT's proven thyromimetic activity in other fetal animal models, this thyroid hormone analog failed to prevent cretinism in thyroidectomized fetal lambs even when administered to the ewe at a dose that suppressed maternal thyroid function.
"
07/01/1982 - "
The nonhalogenated thyroid hormone analog 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) was administered to pregnant ewes to determine if this compound could prevent cretinism in the thyroidectomized fetal lamb.
"
5.
Tremor (Tremors)
01/01/1984 - "
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth.
"
Related Drugs and Biologics
1.
3,5-dimethyl-3'-isopropyl-L-thyronine
2.
Thyroid Hormones
3.
Tubulin
4.
Triiodothyronine (Liothyronine)
5.
Thyroxine (Levothyroxine)
6.
Phospholipids (Phosphatides)
7.
Lipids
8.
3,3',5-triiodothyroacetic acid (Triac)