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5-vinyluracil

RN given refers to unlabeled parent cpd

Also Known As:

5-vinyluracil, 1-(3)H-labeled; 5-ethenyl-2,4(1H,3H)-pyrimidinedione

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        5-vinyluracil: 3

Experts

1.	Eda, Hiroyuki: 2 articles (09/2003 - 03/2003)
2.	Hattori, Kazuo: 2 articles (09/2003 - 03/2003)
3.	Ishikawa, Tohru: 2 articles (09/2003 - 03/2003)
4.	Ishitsuka, Hideo: 2 articles (09/2003 - 03/2003)
5.	Miwa, Masanori: 2 articles (09/2003 - 03/2003)
6.	Shimma, Nobuo: 2 articles (09/2003 - 03/2003)
7.	Tanimura, Hiromi: 2 articles (09/2003 - 03/2003)
8.	Ura, Masako: 2 articles (09/2003 - 03/2003)
9.	Banken, Ludger: 1 article (04/2004)
10.	Bellibas, S Eralp: 1 article (04/2004)

Related Diseases

1.

Neoplasms (Cancer)

09/20/2003 - "As compared to 5-ethynyluracil or 5-vinyluracil, which inhibited DPD not only in tumor tissues but also in other non-cancerous tissues, the effective dose range of RO0094889 in augmenting the efficacy of capecitabine was much broader. "
04/01/2004 - "Ro 09-4889 was designed to enhance the anticancer efficacy of capecitabine (Xeloda) by generating a dihydropyrimidine dehydrogenase inhibitor (DPDi) 5-vinyluracil (5-VU) preferentially in tumor tissues. "
09/20/2003 - "Administration of RO0094889 that is converted to a DPD inhibitor 5-vinyluracil selectively in tumor tissues restored the antitumor activity of capecitabine against the tumor of the HCT116 cells carrying DPD cDNA and various tumors expressing DPD. "
03/10/2003 - "RO0094889 (11c) is a prodrug of 5-vinyluracil (4c), a known DPD inhibitor, and was designed to generate 4c selectively in tumor tissues by sequential conversion of 11c by three enzymes: esterase, cytidine deaminase and thymidine phosphorylase, the latter two of which are known to be highly expressed in various tumor tissues. "

Related Drugs and Biologics

1.	2',3'- O- diacetyl- 5'- deoxy- 5- vinylcytidine
2.	Capecitabine (Xeloda)
3.	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
4.	eniluracil
5.	Complementary DNA (cDNA)
6.	Thymidine Phosphorylase
7.	Prodrugs
8.	Esterases
9.	Enzymes
10.	Cytidine Deaminase