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rutamarin

RN given refers to parent cpd; structure

Also Known As:

2-(1-acetyloxy)-(1-methylethyl)-6-(1,1-dimethyl-2-propenyl)-2,3-dihydro-7H-furo(3,2-g)(1)benzopyran- 7-one

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - rutamarin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - rutamarin: 4

Experts

1.	Wang, Yan: 2 articles (07/2014 - 01/2014)
2.	Yuan, Yan: 2 articles (07/2014 - 01/2014)
3.	Akbar, Idhayadhulla: 1 article (01/2021)
4.	Alfarhan, Ahmed H: 1 article (01/2021)
5.	Chidambaram, Sathishkumar: 1 article (01/2021)
6.	El-Sheikh, Mohamed A: 1 article (01/2021)
7.	Radhakrishnan, Surendrakumar: 1 article (01/2021)
8.	Abdul Malek, Sri Nurestri: 1 article (07/2017)
9.	Hong, Sok Lai: 1 article (07/2017)
10.	Suhaimi, Shafinah Ahmad: 1 article (07/2017)

Related Diseases

1.	Epstein-Barr Virus Infections 07/01/2014 - "In particular, (+)-rutamarin, with the best selectivity index (SI>63) among the inhibitors tested in this study, is effective in inhibiting EBV DNA replication and virion production but shows little adverse effect on cell proliferation, suggesting its potential to become an efficacious and safe drug for the treatment of human diseases associated with EBV infection. "
2.	Infections 01/01/2014 - "This study demonstrated great potential for (+)-rutamarin to become an effective drug for treatment of human diseases associated with KSHV infection. "
3.	Colonic Neoplasms (Colon Cancer) 07/01/2017 - "Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line." 07/01/2017 - "Rutamarin was cytotoxic to HT29 colon cancer cells but exerted no damage to normal colon cellsRutamarin induced morphological and biochemical hallmarks of apoptosis in HT29 cellsRutamarin induced cell cycle arrest at the G0/G1 and G2/M checkpoints in a dose-dependent manner in HT29 cellsRutamarin activated caspases 3, 8, and 9 in a dose-dependent manner in HT29 cells. "
4.	Carcinoma (Carcinomatosis) 07/01/2017 - "Eight compounds including rutamarin were isolated from the active chloroform extract and evaluated for their cytotoxic activity against HT29 human colon carcinoma cell line and CCD-18Co noncancer cells. "
5.	COVID-19 01/01/2021 - "The recently synthesised compounds were projected conceptual association for COVID-19 protease and also to explore in anticipation if this protein will help target protease inhibitor drugs such as Calanolide A, Cardatolide A, Collinin, Inophyllum A, Mesuol, Isomesuol, Pteryxin, Rutamarin, Seselin and Suksdorin. "

Related Drugs and Biologics

1.	Caspases
2.	Proteins (Proteins, Gene)
3.	Protease Inhibitors (Protease Inhibitor)
4.	Peptide Hydrolases (Proteases)
5.	Chloroform (Trichloromethane)
6.	collinin
7.	seselin
8.	4-phenylcoumarin
9.	calanolide A
10.	pteryxin