IMET 3146

RN given refers to parent cpd without isomeric designation

Also Known As:

IMET 3146, (+-)-isomer; IMET 3146, hydrochloride, (+-)-isomer; ZIMET 3164; alpha-amino-5-(bis(2-chloroethyl)amino)-1-phenyl-1H-benzimidazole-2-propanoic acid

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - IMET 3146: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        IMET 3146: 3

Related Diseases

1.	Sarcoma 180 12/01/1979 - "ZIMET 3164 inhibited the growth of sarcoma 180 P, sarcoma 180 G, and Walker 256 carcinosarcoma, but was unable to prolong the survival time of mice bearing Ehrlich ascites carcinoma or the leukaemias L 1210 and LAJ I to a worthwhile extent. "
2.	Nephritis 12/01/1979 - "Beta-[1-Phenyl-5-bis(beta-chloroethyl)-amino-benzimidazolyl-(2)]-DL-alanin (ZIMET 3164), a highly immunosuppressive but moderately cytostatic agent, was found to be able to prevent the progression of spontaneous murine immune complex nephritis in a dose-dependent fashion. " 12/01/1979 - "Therapeutic effect of beta-[1-phenyl-5-bis(beta-chloroethyl)-amino-benzimidazolyl-(2)-DL-alanin (ZIMET 3164) on immune complex nephritis of NZB hybrid mice."
3.	Neoplasms (Cancer) 12/01/1979 - "Beta-[1-Phenyl-5-bis(beta-chloroethyl)-amino-benzimidazolyl-(2)]-DL-alanine (ZIMET 3164): an immunosuppressant without marked anti-cancer effect."
4.	Hemolysis 01/01/1979 - "However, the highest reduction of the electrophoretic mobility and protection from filipin-induced hemolysis of pretreated RBC was found with ZIMET 3164. " 01/01/1979 - "The influence on red blood cells (RBC) of two cancerostatic-(ZIMET 3106 and ZIMET 3393) and two immunomodulating agents (ZIMET 3164 and ZIMET 86/76) administered subcutaneously, or intraperitoneally in case of the radiolabelled N-mustard compounds, to mice, was studied by means of measurements of the radiolabelled compounds in blood, by cell electrophoresis, filipin-induced hemolysis of pretreated RBC and by scanning electronmicroscopy. "
5.	Carcinosarcoma 12/01/1979 - "ZIMET 3164 inhibited the growth of sarcoma 180 P, sarcoma 180 G, and Walker 256 carcinosarcoma, but was unable to prolong the survival time of mice bearing Ehrlich ascites carcinoma or the leukaemias L 1210 and LAJ I to a worthwhile extent. "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Therapeutic Uses
3.	Mustard Compounds
4.	Immunosuppressive Agents (Immunosuppressants)
5.	Filipin (Filipin III)
6.	Antigen-Antibody Complex (Immune Complex)
7.	Alanine (L-Alanine)
8.	Immunomodulating Agents
9.	Bendamustine Hydrochloride
10.	ZIMET 86-76