curcumol

01/01/2020 - "Besides, curcumol protection against chronic CCl4-caused hepatic fibrosis could be impaired by POSTN overexpression. "
01/01/2020 - "To study the effect of curcumol on liver sinusoidal endothelial cells (LSECs) and to analyze the mechanism of antihepatic fibrosis. "
10/01/2018 - "In summary, our study results reveal the molecular mechanism of curcumol-induced HSC necroptosis, and suggest a potential clinical use of curcumol-targeted RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling for the treatment of hepatic fibrosis."
12/01/2022 - "To explore the effect of curcumol on autophagy and ferroptosis of hepatic stellate cells, and to clarify the molecular mechanism of its anti-hepatic fibrosis. "
01/01/2020 - "Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling pathway and increasing the fenestrae of LSECs."

10/01/2021 - "Moreover, further study showed that the differential expression of NCL and curcumol intervention only had a regulatory effect on the nuclear accumulation of VEGFR1, which strengthened the anti-cancer effect of curcumol mediated through NCL. "
01/01/2015 - "In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. "
11/01/2023 - "Curcumol, as an active extract from traditional Chinese medicines, has been reported to have antitumor activity in various types of human tumor cells. "
10/20/2023 - "Curcumol, but not TMZ, produced significant inhibitory effect on tumor growth in the tumor-bearing mice (P<0.01). "
07/01/2023 - "However, the role of NCL in cancer autophagy and in curcumol's anti-tumor effects haven't elucidated. "

01/01/2022 - "To study the mechanism of curcumol affecting the proliferation and apoptosis of liver cancer cells through the DJ-1/PTEN/PI3K/AKT pathway. "
01/01/2022 - "(2) Compared with the blank control group and the 10 and 30 μg/mL concentration groups, the proliferation level of liver cancer cells in the 100 μg/mL curcumol group was significantly reduced, and the proportion of cell apoptosis was significantly increased (p < 0.05). "
07/15/2020 - "These results illustrated that curcumol inhibits the expression of PD-L1 through crosstalk between HIF-1α and p-STAT3 (T705) signaling pathways in hepatic cancer. "
08/01/2018 - "Collectively, these results demonstrate that galactosylated-liposomes are able to enhance the in vitro liver-targeting effect and anti-liver cancer efficacy of curcumol."
01/01/2022 - "(3) Curcumol can significantly increase the expression of PTEN gene and protein in liver cancer cells and reduce the expression of DJ-1 and PI3K genes and protein in liver cancer cells (p < 0.05). "

01/10/2018 - "To assess the effect of curcumol on cell cycle arrest against human colon cancer cells (CRC) cells (LoVo and SW480) and explore its mechanism in vitro and in vivo. "
01/01/2022 - "Therapeutic targets and functions of curcumol against COVID-19 and colon adenocarcinoma."
05/01/2021 - "Our study showed the potent antitumor effect of curcumol by induction of apoptosis, inhibition of proliferation, invasion, migration, and improvement of the therapeutic efficacy of 5-FU toward human colon cancer HCT116 cells. "
05/01/2021 - "Curcumol as a potential chemotherapeutic agent combined with 5-FU can overcome colon cancer resistance."
05/01/2021 - "Therefore, we studied the antitumor effect of curcumol alone or combined with 5-FU on human colon cancer drug-resistant cells. "

09/01/2023 - "Curcumol inhibited the inflammation and apoptosis induced by ISO and TGF-β1 in mouse myocardium and neonatal rat cardiomyocytes (NRCMs). "
08/01/2022 - "Molecular biological testing found that curcumol could significantly improve the pathological changes of the liver tissue and inhibit the occurrence of liver inflammation. "
11/01/2021 - "Curcumol has been shown to alleviate inflammation in various disease models, but its effects on IVDD remain unclear. "
08/01/2022 - "The effect of curcumol on liver fibrosis may be related to its regulation of intestinal flora and the resulting interference with metabolic pathways, thereby reducing liver inflammation."
11/01/2021 - "Curcumol Alleviates the Inflammation of Nucleus Pulposus Cells via the PI3K/Akt/NF-κB Signaling Pathway and Delays Intervertebral Disk Degeneration."