|1.||Liu, Yunpeng: 11 articles (01/2016 - 01/2009)|
|2.||Chung, Jing-Gung: 9 articles (01/2015 - 01/2012)|
|3.||Qu, Xiujuan: 7 articles (01/2016 - 01/2009)|
|4.||Zhu, Zhitu: 6 articles (01/2016 - 09/2010)|
|5.||Gu, Wei: 6 articles (01/2015 - 03/2007)|
|6.||Wang, Jin: 5 articles (01/2015 - 05/2007)|
|7.||Yang, Jai-Sing: 5 articles (01/2014 - 01/2012)|
|8.||Ma, Yanju: 4 articles (01/2016 - 07/2014)|
|9.||Teng, Yuee: 4 articles (01/2016 - 01/2009)|
|10.||Wang, Ying: 4 articles (07/2015 - 01/2012)|
04/01/2009 - "Our study provides new insights into the molecular mechanisms of bufalin, might prove to be beneficial in leukemia therapy."
07/01/2000 - "To study the mechanism of bufalin on human leukemia cell inhibition. "
12/01/1995 - "The aim of this study was to explore an endogenous bufalin-like factor that induces leukemia cell differentiation. "
08/01/1995 - "In the present study, we found that bufalin at concentrations of 10(-7) M and higher induced apoptosis in human leukemia cells, such as HL60, ML1, but not in mouse leukemia M1 cells. "
12/01/2014 - "The human leukemia multidrug resistant K562/VCR cells showed no cross-resistance to bufalin. "
01/01/2014 - "A large number of studies have shown that bufalin can have a significant antitumor effect in a variety of tumors. "
01/01/2013 - "A number of studies have demonstrated that bufalin can induce apoptosis in some cancers. "
01/01/2012 - "Large-scale randomized, double-blind, placebo or positive drug parallel controlled studies are now required to confirm the efficacy and apoptosis-inducing potential of bufalin in various cancers in the cliniucal setting."
01/01/2012 - "Results of multiple studies indicate that bufalin has marked anti-tumor activities through its ability to induce apoptosis. "
02/01/2007 - "Previous study revealed that bufalin can inhibit proliferation, and induce apoptosis in some human cancer cell lines. "
|3.||Lung Neoplasms (Lung Cancer)
01/01/2014 - "Bufalin has been shown effective in inducing apoptosis and DNA damage in lung cancer cells. "
09/01/2015 - "In the present study, the effect of bufalin on TGF‑β‑induced EMT and migration was investigated in human lung cancer A549 cells. "
01/01/2013 - "Our studies showed that bufalin could reverse resistance to reversible and irreversible EGFR-TKIs induced by exogenous HGF in EGFR mutant lung cancer cells by inhibiting the Met/PI3K/Akt pathway and inducing death signaling. "
01/01/2013 - "The purpose of this study was to determine whether bufalin, a major bioactive component of Venenum Bufonis, could reverse HGF-induced resistance to reversible and irreversible EGFR-TKIs in mutant lung cancer cells PC-9, HCC827, and H1975. "
09/01/2015 - "Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors."
|4.||Colonic Neoplasms (Colon Cancer)
01/01/2012 - "Bufalin not only inhibited the growth of colon cancer SW620 cells, but also induced apoptosis of SW620 cells. "
01/01/2012 - "The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells. "
01/01/2012 - "Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells."
10/01/2011 - "In this study, the effects of bufalin isolated from a traditional Chinese medicine were evaluated and characterized in HT-29 and Caco-2 human colon cancer cells. "
10/01/2011 - "Our findings unveil a novel mechanism of drug action by bufalin in colon cancer cells and open up the possibility of treating colorectal cancer through a ROS-dependent autophagy pathway."
|5.||Neoplasm Metastasis (Metastasis)
01/01/2016 - "In the present study, the colony formation assay, the Transwell invasion assay, the western blot analysis and the immunofluorescence method were respectively used to investigate the effect and mechanism of bufalin against HCC cell invasion and metastasis. "
01/01/2016 - "These are very important mechanisms of bufalin on the inhibition of the invasion and metastasis of HCC cells. "
03/01/2014 - "This study revealed that bufalin inhibited angiogenesis and regulated miR-497 expression and that bufalin and miR-497 acted in synergy to inhibit colorectal cancer metastasis, resulting in improved quality of life in a nude mouse model. "
03/01/2014 - "The study aims to investigate the effect of microRNA-497 (miR-497) expression and bufalin treatment in regulating colorectal cancer invasion and metastasis. "
01/01/2013 - "In the present study, we investigated the inhibitory effects of bufalin on cell migration and invasion, two critical cellular processes that are often deregulated during metastasis, using the human bladder cancer cell line, T24. "
|3.||Polyethylene Glycols (Polyethylene Glycol)
|5.||Glycine (Aminoacetic Acid)
|6.||Aspartic Acid (Aspartate)
|8.||polylactic acid-polyglycolic acid copolymer (PLGA)
|9.||glycolic acid (glycolate)
|10.||monomethoxypolyethylene glycol (MPEG)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|2.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)
|5.||Transplantation (Transplant Recipients)