2-bromopalmitate

inhibitor of fatty acid oxidation; RN given refers to parent cpd

Also Known As:

2-bromohexadecanoic acid; 2-bromopalmitate, (+-)-isomer; 2-bromopalmitate, 77Br-labeled; 2-bromopalmitate, potassium salt; alpha-bromopalmitate

Networked: 22 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Palmitic Acids: 35
    - Palmitates: 1597
      - 2-bromopalmitate: 22

Experts

1.	Xie, Min: 2 articles (01/2021 - 01/2019)
2.	Li, Feng-Ping: 1 article (06/2022)
3.	Li, Zhi-Qiang: 1 article (06/2022)
4.	Pan, Zhi-Yong: 1 article (06/2022)
5.	Tang, Feng: 1 article (06/2022)
6.	Wang, Ze-Fen: 1 article (06/2022)
7.	Yang, Chao: 1 article (06/2022)
8.	Yu, Dong-Hu: 1 article (06/2022)
9.	Chen, Shang: 1 article (05/2022)
10.	Fan, Guangchun: 1 article (05/2022)

Related Diseases

1.	Pain (Aches) 01/12/2021 - "2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function." 01/01/2019 - "2-Bromopalmitate attenuates bone cancer pain via reversing mitochondrial fusion and fission imbalance in spinal astrocytes." 01/12/2021 - "In the present study, we aimed to explore the effects of 2-bromopalmitate (2-BP), an inhibitor of protein palmitoylation, on the modulation of pain behavior. " 01/01/2022 - "This study explored the neuropathy of chemotherapy pain and investigated the analgesic effect of 2-bromopalmitate (2-BP) on the pain behavior of OXA-induced rats. "
2.	Infections 10/26/2021 - "Treatment of infected cells with the palmitoylation inhibitor 2-bromopalmitate (2-BP) significantly suppressed SADS-CoV infection. " 01/01/2023 - "In this study, we initially observed that the inhibition of palmitoylation by 2-bromopalmitate (2-BP) enhanced ZIKV infections, and determined that the envelope protein of ZIKV is palmitoylated at Cys308. "
3.	Neoplasms (Cancer) 10/01/2023 - "In vivo Panc 02 subcutaneous tumor model validated the anti-tumor effect of knockdown of ZDHHC3 or intraperitoneal injection of 2-bromopalmitate (2-BP), a typical broad-spectrum palmitoyl transferases inhibitor. " 03/07/2023 - "Particularly, targeting β-catenin palmitoylation by 2-bromopalmitate (2-BP) can efficiently inhibit β-catenin-dependent tumor growth in vivo, and pharmacological inhibition of DUSP14-ACOX1-β-catenin axis by Nu-7441 reduced the viability of CRC cells. " 05/22/2019 - "Furthermore, TKI-induced EGFR dimerization is persistent in TKI-resistant cells, and inhibition of palmitoylation by 2-bromopalmitate, or targeted reduction of the kinase-inactivated EGFR by siRNA or by an EGFR-downregulating peptide, are lethal to TKI-resistant cancer cells. "
4.	Hepatocellular Carcinoma (Hepatoma) 11/21/2023 - "Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate." 09/01/2004 - "Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation." 08/18/1995 - "In primary rat hepatocytes and Fa-32 hepatoma cells C-ACS mRNA increased after treatment with fenofibric acid, alpha-bromopalmitate, tetradecylthioacetic acid, or alpha-linolenic acid. "
5.	Neuralgia (Stump Neuralgia) 01/01/2022 - "2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction." 01/01/2018 - "Inhibiting palmitoyl acyltransferases or decreasing δ-catenin abundance in the DRG by intrathecal injection of 2-bromopalmitate or shRNA, respectively, alleviated oxaliplatin or nerve injury-induced neuropathic pain in the rats. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Analgesics (Analgesic Drugs)
3.	Catenins
4.	Small Interfering RNA (siRNA)
5.	Oxaliplatin (Eloxatin)
6.	Betacellulin
7.	ErbB Receptors (EGF Receptor)
8.	Interleukin-1 Receptor-Associated Kinases
9.	Desmoglein 2
10.	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Spinal Injections
3.	Intraperitoneal Injections
4.	Aftercare (After-Treatment)