thiopurine methyltransferase (thiopurine S-methyltransferase)

01/01/2022 - "In this study, the correlation between genotypes (thiopurine S-methyltransferase, NUDT15, and ITPA polymorphisms), 6-TGN concentrations, and clinical outcomes (efficacy and side effects) in patients with inflammatory bowel disease were investigated. "
07/01/2005 - "The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD). "
05/01/2005 - "Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease."
01/01/2020 - "Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population."
08/05/2019 - "Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients."

07/15/2017 - "In addition to variation in TPMT (thiopurine S-methyltransferase), the NUDT15 p.R139C variant was recently identified to have a strong association with AZA-induced leukopenia. "
09/01/2014 - "This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). "
05/01/2012 - "Routine thiopurine methyltransferase testing before the initiation of AZA will reduce early leukopenia and is mandatory to avoid potentially life-threatening myelotoxicity. "
01/01/2010 - "Patients with intermediate or low thiopurine methyltransferase activity are at risk for early leukopenia. "
01/01/2018 - "The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. "

01/01/2016 - "Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review."
01/01/2016 - "Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy."
01/01/2013 - "Polymorphisms in thiopurine S-methyltransferase (TPMT) gene have been associated with adverse drug reactions (ADRs) to AZA. "
05/01/2007 - "The thiopurine methyltransferase (TPMT) 719A>G single-nucleotide polymorphism (SNP) causes decreased TPMT activity, increased intracellular thiopurines, and drug toxicities. "
01/01/2007 - "Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events."

12/01/2003 - "For the purpose of clarifying the influence of thiopurine methyltransferase (TPMT) gene single nucleotide polymorphisms (SNPs) on the efficacy of thiopurines and risk for its toxicity and therefore improving the safety and efficacy of thiopurines, the authors investigated TPMT genotype in acute leukemia in children who were intolerant to the treatment with 6-mercap topurine (6-MP). "
01/01/2017 - "We performed a genomewide association study (GWAS) of primary erythrocyte thiopurine S-methyltransferase (TPMT) activity in children with leukemia (n = 1,026). "
01/01/2018 - "Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia. "
01/01/2018 - "Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia."
11/15/2013 - "Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells."

12/01/2013 - "This study was conducted to investigate the thiopurine S-methyltransferase TPMT activity distribution and gene mutations in Tunisian population with positive diagnostic for Crohn's disease. "
01/01/2020 - "The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn's Disease."
12/01/2013 - "Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease."
01/01/2003 - "Thiopurine methyltransferase genotype distribution in patients with Crohn's disease."
01/01/2016 - "Thiopurines are used in the treatment of Crohn's disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events. "