thiaminase II (thiaminase)

03/01/1956 - "Studies on thiamine deficiency due to bacterial thiaminase. "
02/10/1955 - "Studies on the thiamine deficiency due to bacterial thiaminase. "
07/10/1954 - "Studies on the thiamine deficiency due to bacterial thiaminase. "
10/24/2023 - "These data provide a foundation for understanding sources of thiaminase leading to thiamine deficiency in fisheries and other organisms, including humans that eat uncooked fish."
12/01/2010 - "The objective was to measure thiaminase activity in forage fish (alewife Alosa pseudoharengus, rainbow smelt Osmerus mordax, and slimy sculpin Cottus cognatus) consumed by predators that manifest thiamine deficiency using both methods. "

05/01/1977 - "Three flocks in which in with one of more sheep had succumbed to polioencephalomalacia (cerebrocortical necrosis) were used for faecal thiaminase studies. "
11/24/1979 - "Cerebrocortical necrosis in ruminants: effect of thiaminase type 1-producing Clostridium sporogenes in lambs."
10/01/1977 - "Cerebrocortical necrosis in ruminants: an attempt to identify the source of thiaminase in affected animals."
04/01/1974 - "A rapid radioactive method for determination of thiaminase activity and its use in the diagnosis of cerebrocortical necrosis in sheep and cattle."
05/01/1971 - "The implication of ruminal thiaminase in cerebrocortical necrosis."

01/01/2014 - "Now, we first show further evidence of thiaminase therapeutic potential by demonstrating its activity against breast and leukemia xenografts, and against a primary leukemia xenograft. "
06/01/2012 - "Despite superior pharmacokinetics, 5k-PEGylated thiaminase showed no antitumor effect against an RS4 leukemia xenograft, in contrast to native thiaminase, which showed antitumor activity. "
01/01/2014 - "We therefore further explored the metabolic effects of thiaminase in combination with rapamycin in leukemia and breast cell lines. "
01/01/2014 - "Interestingly, thiaminase suppression of another TDE, branched chain amino ketoacid dehydrogenase (BCKDH), showed very different patterns in the two cell lines: in RS4 leukemia cells it led to an increase in BCKDH substrates, and in MCF-7 breast cancer cells it led to a decrease in BCKDH products. "
06/01/2012 - "However, native enzyme more effectively depleted thiamine and thiamine diphosphate in RS4 leukemia cell cytosol, and native thiaminase depressed cellular respiration, whereas PEGylated thiaminase did not. "

01/01/2019 - "Over the past century, populations of Lake Trout Salvelinus namaycush have declined throughout the Great Lakes basin due to overfishing, habitat destruction, introduction of invasive species, and associated recruitment issues from high thiaminase, as well as emerging infectious diseases. "

05/01/2013 - "Wernicke's encephalopathy secondary to hyperthyroidism and ingestion of thiaminase-rich products."