|1.||Blau, Nenad: 4 articles (01/2015 - 12/2006)|
|2.||Friedman, Jennifer: 3 articles (08/2015 - 12/2006)|
|3.||Hyland, Keith: 3 articles (04/2012 - 12/2006)|
|4.||Leuzzi, Vincenzo: 2 articles (08/2015 - 12/2013)|
|5.||Tolve, Manuela: 2 articles (08/2015 - 12/2013)|
|6.||Angeloni, Antonio: 2 articles (08/2015 - 12/2013)|
|7.||Carducci, Carla: 2 articles (08/2015 - 12/2013)|
|8.||Carducci, Claudia: 2 articles (08/2015 - 12/2013)|
|9.||Geerts, Dirk: 2 articles (01/2015 - 01/2014)|
|10.||Mocz, Gabor: 2 articles (01/2015 - 01/2014)|
|1.||Schizophrenia (Dementia Praecox)
09/01/2010 - "The development of a novel strain of mutant mice that is deficient in BH(4) by knocking out the expression of a functional sepiapterin reductase gene (spr -/-) has added new insights into the potential role of BH(4) in the pathophysiology and improved treatment of schizophrenia."
01/01/2015 - "Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population."
01/01/2015 - "Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of schizophrenia via dysregulation of neurotransmitter systems. "
|2.||Parkinson Disease (Parkinson's Disease)
11/01/2011 - "Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease."
03/30/2007 - "Sepiapterin reductase expression is increased in Parkinson's disease brain tissue."
07/01/2006 - "Recently, a haplotype across the sepiapterin reductase (SPR) gene, which is located in the PARK3 linkage region, was shown to modulate age of onset of Parkinson's disease in sibships from North America. "
07/01/2006 - "The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations."
11/01/2011 - "Sepiapterin reductase (SPR) gene is an enzyme which catalyses the final step of tetrahydrobiopterin synthesis (BH4) and was implicated in Parkinson's disease (PD) pathogenesis as a candidate gene for PARK3 locus. "
01/01/2015 - "Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target."
01/23/2014 - "Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation."
11/28/1997 - "The amounts of messenger RNA for three enzymes, namely guanosine triphosphate (GTP) cyclohydrolase 1,6-pyruvoyltetrahydropterin synthase, and sepiapterin reductase, all of which are involved in the de novo biosynthesis of (6R)-L-erythrodihydroxypropyl-2-amino-4-hydroxy-5,6,7,8-tetrahydro pteridine (BH4) from GTP, were measured quantitatively in murine neuroblastoma cell line N1E-115 by the competitive polymerase chain reaction (PCR) technique after reverse transcription using a heterologous DNA fragment as an internal standard. "
|4.||Parkinsonian Disorders (Parkinsonism)
09/15/2011 - "BH4 deficiency due to autosomal recessive mutations in all enzymes, except for sepiapterin reductase, has been described as a cause of hyperphenylalaninaemia. "
04/01/2000 - "With regard to human disease, BH(4) deficiency due to autosomal recessive mutations in all enzymes (except sepiapterin reductase) have been described as a cause of hyperphenylalaninaemia. "
|2.||GTP Cyclohydrolase (GTP Cyclohydrolase I)
|4.||Levodopa (L Dopa)
|6.||Nitric Oxide Synthase (NO Synthase)
|7.||Neurotransmitter Agents (Neurotransmitter)
|8.||Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
|9.||Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
|10.||Growth Hormone (Somatotropin)