|1.||Ilinskaya, Olga N: 4 articles (12/2014 - 10/2007)|
|2.||Il'inskaia, O N: 3 articles (01/2014 - 05/2005)|
|3.||Makarov, Alexander A: 3 articles (07/2013 - 10/2007)|
|4.||Mitkevich, Vladimir A: 3 articles (07/2013 - 10/2007)|
|5.||Vershinina, Valentina: 2 articles (01/2015 - 10/2011)|
|6.||Ulyanova, Vera: 2 articles (01/2015 - 10/2011)|
|7.||Ilinskaya, Olga: 2 articles (01/2015 - 10/2011)|
|8.||Zelenikhin, P V: 2 articles (01/2014 - 05/2005)|
|9.||Petrushanko, Irina Y: 2 articles (07/2013 - 12/2011)|
|10.||Gärtner, Jutta: 2 articles (09/2012 - 01/2011)|
12/15/2014 - "Binase did not induce alteration of EZH2 (enhancer of zeste-homolog-2) protein expression neither, in tumor nor in normal cells. "
01/01/2014 - "Flow cytometry was used to determine that binase concentration causing the apoptosis of cancer cells had no effect of the viability of Escherichia coli K12. "
07/01/2013 - "In this work the antitumor potential of binase was evaluated in vivo and the mechanism of cytotoxic effect of binase on tumor cells was comprehensively studied in vitro. "
07/01/2013 - "The tumor transformation led to the modification of certain cellular characteristics causing cell sensitivity to binase. "
09/01/2012 - "In recent years, new functions such as tumor suppressing properties of RNase T2 have been reported that are independent of its catalytic activity. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
12/15/2014 - "Binase decreased viability and induced the selective apoptosis of ovarian cancer cells. "
12/15/2014 - "In conclusion, selective binase-induced cell death and apoptosis via poly(ADP-ribose) polymerase fragmentation may serve as a new treatment option against ovarian cancer progression. "
12/15/2014 - "The cytotoxic effects of Bacillus intermedius RNase (binase) towards ovarian cancer cells (SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1 and HOSE2). "
07/01/2014 - "Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer."
12/15/2014 - "Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells."
|3.||Neoplasm Metastasis (Metastasis)
06/01/2014 - "Binase at doses of 0.1-1 mg/kg which produced effective suppression of tumor growth and metastasis, showed positive effect on the liver of tumor-bearing mice expressed in a significant reduction in the volume of destructive changes in the liver parenchyma and return to the normal level of the liver regenerative potential impaired due to endogenous intoxication and tumor burden."
07/01/2013 - "Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells."
07/01/2013 - "We show for the first time that intraperitoneal injection of binase at a dose range 0.1-5 mg/kg results in retardation of primary tumor growth up to 45% in LLC and RLS 40 and inhibits metastasis up to 50% in LLC and RLS 40 and up to 70% in B-16 melanoma. "
01/01/2015 - "These results, together with our demonstration that binase-like RNases are induced in response to phosphate starvation, allow us to categorise this group of ribonucleases as new members of Bacillus PhoP regulon. "
10/01/2011 - "Binase is predominantly synthesized under phosphate starvation, whereas barnase production is strictly dependent on the multifunctional Spo0A regulator controlling sporulation, biofilm formation and cannibalism. "
05/01/2000 - "This would allow attenuator control over binase II expression under conditions of starvation for ferric ions."
05/01/2000 - "intermedius enzymes are induced upon phosphate starvation, only the gene for binase I belongs to the pho regulon system and carries pho-box elements adjacent to its promoter sequence. "
01/01/2006 - "Ribonuclease LX (RNaseLX) from tomato (Solanum lycopersicum L.) belongs to the RNase T2/S-RNase superfamily of plant endoribonucleases and this is a report on the characterization of the RNaseLX gene and its encoded protein as a member of the phosphate starvation response in tomato. "
|1.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|5.||Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)
|6.||Caspase 8 (Caspase-8)
|7.||Staphylococcal Protein A (A, Protein)
|9.||RNA (Ribonucleic Acid)
|10.||Proteins (Proteins, Gene)