|1.||Jakobsson, Per-Johan: 27 articles (07/2015 - 10/2002)|
|2.||Uematsu, Satoshi: 19 articles (12/2015 - 06/2004)|
|3.||Akira, Shizuo: 18 articles (12/2015 - 06/2004)|
|4.||Korotkova, Marina: 11 articles (06/2015 - 11/2005)|
|5.||Kudo, Ichiro: 11 articles (07/2013 - 12/2002)|
|6.||Blomqvist, Anders: 10 articles (10/2014 - 10/2002)|
|7.||Murakami, Makoto: 9 articles (01/2010 - 05/2003)|
|8.||Geisslinger, Gerd: 8 articles (04/2015 - 08/2006)|
|9.||Jia, Zhanjun: 8 articles (01/2014 - 11/2006)|
|10.||Yang, Tianxin: 8 articles (01/2014 - 11/2006)|
10/01/2013 - "Consistent with these findings, we observed a significant reduction in multiplicity of tumors ≥1mm in diameter, suggesting that mPGES-1 contributes to mammary tumor growth. "
10/22/2014 - "This study clearly demonstrated that the human COX-2 linked to mPGES-1 is a pathway that, when mediated by the EP, is linked to promoting cancer growth in a chronic inflammatory environment. "
01/01/2006 - "In particular, recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs."
11/30/2005 - "Recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs. "
07/01/2015 - "Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment."
12/15/2013 - "Even though many potent inhibitors of human mPGES-1, tested in vitro assay systems, have been synthesized, they all failed in preclinical trials in rodent models of inflammation, due to the lack of activity on rodent enzyme. "
05/16/2006 - "We focused our study on mPGES-1 expression in the hypothalamus and dorsal vagal complex, two structures strongly activated during peripheral inflammation and involved in the regulation of food intake. "
09/01/2005 - "In this study, we demonstrated the expression of mPGES-1 in the brain parenchyma in a lipopolysaccharide (LPS)-induced inflammation model. "
12/01/2015 - "The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL."
10/15/2015 - "The murine model of AERD, generated by dust mite priming of mice lacking microsomal PGE2 synthase (ptges(-/-) mice), shows a similar upregulation of IL-33 protein in the airway epithelium, along with marked eosinophilic bronchovascular inflammation. "
02/01/2010 - "Microsomal prostaglandin E synthase-1 (mPGES-1) is a recently characterized cytokine-inducible enzyme critically involved in pain and inflammatory response. "
08/01/2007 - "Among them, mPGES-1 is highly inducible by cytokine and is critically involved in pain and inflammatory responses. "
08/01/2006 - "Is mPGES-1 a promising target for pain therapy?"
07/22/2003 - "Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase."
04/01/2013 - "However, they were all shown to be considerably less active on rodent mPGES-1, precluding the study of mPGES-1 inhibition in rodent models of inflammation and pain. "
|4.||Colonic Neoplasms (Colon Cancer)
08/01/2011 - "In the present study, we show that genetic deletion of mPGES-1 affords significant protection against carcinogen-induced colon cancer. "
05/01/2008 - "We also examined the effect of mPGES-1 deletion on carcinogen-induced colon cancer. "
05/01/2006 - "15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells."
05/23/2003 - "Immunohistochemical analyses demonstrated the expression of both COX-2 and mPGES-1 in human colon cancer tissues. "
09/01/2008 - "GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells."
|5.||Chronic Kidney Failure (Chronic Renal Failure)
01/01/2016 - "The selective inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure."
01/01/2016 - "In accordance, downregulation of microsomal prostaglandin E synthase (mPGES)-1 in VSMCs, mPGES-1(-/-) aorta with high-Pi stimulation and mPGES-1(-/-) chronic renal failure mice resulted in enhanced vascular mineralization. "
01/01/2012 - "In the present study, we investigated the role of mPGES-1 in the development of chronic renal failure in mice with 5/6 nephrectomy (Nx). "
01/01/2012 - "We conclude that mPGES-1 deletion ameliorates chronic renal failure in the mouse model of renal mass reduction, and mPGES-1 deletion paradoxically exacerbates anemia in this model likely via suppression of erythropoietin synthesis."
|1.||Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
|3.||Prostaglandins E (PGE)
|4.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
|5.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|6.||Prostaglandin E Receptors (Prostaglandin E Receptor)
|8.||Proteasome Endopeptidase Complex (Proteasome)
|10.||Cyclooxygenase 2 (Cyclooxygenase-2)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Low-Level Laser Therapy (LLLT)