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phosphoribosylamine-glycine ligase

Also Known As:

GAR synthetase; glycinamide ribonucleotide synthetase; phosphoribosyl-glycineamide synthetase; phosphoribosylglycinamide synthetase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Nitrogen Ligases
      - phosphoribosylamine-glycine ligase: 5

Related Diseases

1.	Trisomy (Trisomies) 01/01/1984 - "The enzymatic activity of phosphoribosylglycinamide synthetase (GARS) has been studied in several cases of partial monosomies and full and partial trisomies 21. "
2.	Sarcoma (Soft Tissue Sarcoma) 05/01/1993 - "Using this targeted cell fusion approach the nutritional markers, uridine monophosphate synthetase (UMPS), mapped onto human chromosome 3 (HSA3), phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase (GART) (HSA21), are reported to be located on sheep chromosome 1q; and phosphoribosyl pyrophosphate amidotransferase (PPAT) (HSA4) has been assigned to sheep chromosome 6. By isozyme analysis and Southern hybridization, transferrin (TF) and superoxide dismutase 1 (SOD1), both in the bovine syntenic group U10, were assigned to sheep chromosome 1q; adenylate kinase 1 (AK1), in the bovine syntenic group U16, to sheep chromosome 3p; lactate dehydrogenase B (LDHB) and phenylalanine hydroxylase (PAH) on bovine chromosome 5 (BTA5) to sheep chromosome 3q; phosphoglucomutase 2 (PGM2) (bovine syntenic group 15) to sheep chromosome 6 (t1q); avian myelocytomatosis viral oncogene homolog (MYC) and Moloney murine sarcoma viral oncogene homolog (MOS) (BTA 14) to sheep 9 (t2q); and glutathione reductase (GSR) (bovine syntenic group U14) to sheep 24 (t1p)."
3.	Lymphoma (Lymphomas) 03/25/1989 - "The enzyme purified from the murine lymphoma cell line L5178Y also catalyzes two other de novo purine biosynthetic activities, glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. "
4.	Down Syndrome (Down's Syndrome) 09/01/1986 - "The levels of glycinamide ribonucleotide synthetase were monitored in four human fibroblast cell lines, two diploid, one monosomy 21 and one trisomy 21, from early passage number to senescence. "
5.	Chromosome Deletion (Deletion, Chromosome) 01/01/1984 - "The enzymatic activity of phosphoribosylglycinamide synthetase (GARS) has been studied in several cases of partial monosomies and full and partial trisomies 21. "

Related Drugs and Biologics

1.	Ligases (Synthetase)
2.	Uridine Monophosphate (UMP)
3.	Transferrin (beta 2 Transferrin)
4.	Ribonucleotides
5.	Phosphoglucomutase
6.	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
7.	Isoenzymes
8.	Glutathione Reductase (Glutathione-Disulfide Reductase)
9.	Enzymes
10.	Amidophosphoribosyltransferase