polyethylene glycol-glutaminase-asparaginase

covalent attachment of polyethylene glycol to nonessential amine groups of enzyme renders it nonimmunogenic for treatment of leukemia (EC 3.5.1.-)

Also Known As:

PEG-L-glutaminase-L-asparaginase; polyethyleneglycol-L-glutaminase-L-asparaginase; Glutaminase-asparaginase

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 06/01/1981 - "The effects of Acinetobacter glutaminase-asparaginase (AGA) on protein and energy requirements were evaluated in mice bearing Ehrlich ascites tumors. " 10/01/1985 - "Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase." 04/01/1981 - "The combined actions of succinylated Acinetobacter glutaminase-asparaginase and 6-diazo-5-oxo-L-norleucine or Acivicin produced synergistic inhibition of nucleic acid synthesis in P388 tumor cells. " 10/01/1985 - "Forty-eight tumor-free mice and 32 mice bearing Ehrlich ascites tumor were randomized into 2 treatments, Acinetobacter glutaminase-asparaginase (AGA) (600 IU/kg/day for 7 days) and 0.9% NaCl controls, and into 2 or 3 isocaloric diets, normal protein (NP) (20 g protein/100 g diet), high protein (HP) (58 g protein/100 g diet), and zero protein (ZP) (tumor-free mice only). "
2.	Ehrlich Tumor Carcinoma 06/01/1981 - "Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase." 10/01/1985 - "Forty-eight tumor-free mice and 32 mice bearing Ehrlich ascites tumor were randomized into 2 treatments, Acinetobacter glutaminase-asparaginase (AGA) (600 IU/kg/day for 7 days) and 0.9% NaCl controls, and into 2 or 3 isocaloric diets, normal protein (NP) (20 g protein/100 g diet), high protein (HP) (58 g protein/100 g diet), and zero protein (ZP) (tumor-free mice only). "
3.	Ascites 06/01/1981 - "The effects of Acinetobacter glutaminase-asparaginase (AGA) on protein and energy requirements were evaluated in mice bearing Ehrlich ascites tumors. " 10/01/1985 - "Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase."
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 06/01/1981 - "Amino acid utilization was evaluated in seven children with acute lymphocytic leukemia treated with succinylated Acinetobacter glutaminase-asparaginase. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/01/1979 - "Effect of succinylated Acinetobacter glutaminase-asparaginase treatment on an acute myeloid leukemia in the rat (BNML)."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nitrogen
3.	GTP-Binding Proteins (G-Protein)
4.	Nucleic Acids
5.	Diazooxonorleucine
6.	Amino Acids
7.	Saline Solution
8.	acivicin (AT 125)

Related Therapies and Procedures

1.	High-Protein Diet