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disaccharide tetrapeptide
isolated from E coli cell wall
Also Known As:
G(Anh)MTetra; N-acetylglucosaminyl-N-AcMu-Ala-gamma-Gln-mesodiaminopimelyl-Ala; N-acetylglucosaminyl-N-acetylmuraminyl-L-alanyl-gamma-D-glutaminylmesodiaminopimelyl-D-alanine; D-Alanine, N-(N-acetyl-4-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)muramoyl)-L-alanyl-D-gamma-glutamyl-meso-alpha,epsilon-diaminopimelyl-
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Amino Sugars: 110
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
disaccharide tetrapeptide: 7
Sugar Acids: 4
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
disaccharide tetrapeptide: 7
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Glycopeptides: 1928
Acetylmuramyl-Alanyl-Isoglutamine: 467
disaccharide tetrapeptide: 7
Experts
1.
Haenssler, Eva
: 1 article (08/2012)
2.
Isberg, Ralph R
: 1 article (08/2012)
3.
Liu, Mingyu
: 1 article (08/2012)
4.
Losick, Vicki P
: 1 article (08/2012)
5.
Park, James T
: 1 article (08/2012)
6.
Uehara, Tsuyoshi
: 1 article (08/2012)
Related Diseases
1.
Whooping Cough (Pertussis)
05/01/1995 - "
The respiratory epithelial pathology of pertussis (whooping cough) can be reproduced by tracheal cytotoxin (TCT), a disaccharide-tetrapeptide released by Bordetella pertussis.
"
03/15/1993 - "
Tracheal cytotoxin (TCT) is a disaccharide-tetrapeptide released by Bordetella pertussis, the causative agent of pertussis (whooping cough).
"
07/01/1989 - "
pertussis, is a disaccharide tetrapeptide subunit of peptidoglycan.
"
2.
Sepsis (Septicemia)
02/11/1994 - "
These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis.
"
3.
Leukocytosis (Pleocytosis)
07/01/1993 - "
The disaccharide-tetrapeptide, the major component of all gram-negative peptidoglycans, induced CSF leukocytosis and protein influx at doses as low as 0.4 microgram (0.42 nM).
"
4.
Legionnaires' Disease (Legionnaire's Disease)
08/16/2012 - "
Upon Legionella pneumophila infection of macrophages, the cytosolic PRR Nod1 recognizes anhydro-disaccharide-tetrapeptide (anhDSTP) generated by soluble lytic transglycosylase (SltL), the predominant bacterial peptidoglycan degrading enzyme, to activate NF-κB-dependent innate immune responses.
"
5.
Hypersensitivity (Allergy)
07/01/1989 - "
The T cell line specific for a bacterial cell wall peptidoglycan subunit, disaccharide tetrapeptide of diaminopimelic acid type, was examined for epitope specificity in elicitation of delayed-type hypersensitivity (DTH) in X-irradiated Lewis rats, using pairs of analogs different in optical configuration of the COOH-terminal amino acid.
"
Related Drugs and Biologics
1.
Peptidoglycan (Murein)
2.
Cytotoxins (Cytolysins)
3.
Interleukin-1beta (Interleukin 1 beta)
4.
Cytokines
5.
Interleukin-6 (Interleukin 6)
6.
Proteins (Proteins, Gene)
7.
Enzymes
8.
Diaminopimelic Acid
9.
Epitopes
10.
Amino Acids