|1.||Rodriguez, Carlos O: 2 articles (03/2008 - 06/2002)|
|2.||Gandhi, Varsha: 2 articles (03/2008 - 06/2002)|
|3.||Gandhi, V: 2 articles (04/2001 - 08/2000)|
|4.||Rodriguez, C O: 2 articles (04/2001 - 08/2000)|
|5.||Ramakrishna, P: 2 articles (04/2001 - 08/2000)|
|6.||Keating, M J: 2 articles (04/2001 - 08/2000)|
|7.||Du, M: 2 articles (04/2001 - 08/2000)|
|8.||Plunkett, W: 2 articles (04/2001 - 08/2000)|
|9.||Yamauchi, Takahiro: 1 article (02/2010)|
|10.||Nakano, Tsuyoshi: 1 article (02/2010)|
|1.||Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
02/01/2010 - "The ara-GTP production was compared between T-lymphoblastic leukemia CCRF-CEM and ATL cell lines in vitro. "
10/01/1999 - "9-Beta-D-Arabinosylguanine (ara-G) is a recently introduced and effective treatment for T-cell acute lymphoblastic leukemia, but how ara-G and ara-G triphosphate (ara-GTP) kill cells is not known. "
06/01/2002 - "The prodrug of 9-beta-D-arabinosylguanine (ara-G), nelarabine, demonstrated efficacy against T-cell acute lymphoblastic leukemia, and its effectiveness correlated with the accumulation of the triphosphate form (ara-GTP). "
|2.||Hematologic Neoplasms (Hematological Malignancy)
06/01/2005 - "Clinical studies evaluating the pharmacokinetics of nelarabine, ara-G, and cellular ara-GTP and use of nelarabine, alone or in combination with other agents for the treatment of hematologic malignancies, were included in this review. "
06/01/2005 - "To present the pharmacology and pharmacokinetics of nelarabine, 9-beta-D-arabinofuranosylguanine (ara-G) and intraleukemic cellular pharmacokinetics of 9-beta-D-arabinofuranosylguanine triphosphate (ara-GTP) generated from the administration of nelarabine, and clinical and safety information relative to nelarabine use in the treatment of hematologic malignancies. "
06/01/2002 - "Evaluation of the expression of each of these kinases in primary leukemia cells may reveal a biochemical basis for the pharmacological differences in the accumulation of ara-GTP."
11/01/1998 - "The pharmacokinetics of ara-GTP in leukemia cells are strongly correlated with clinical responses to GW506U78."
08/18/2000 - "To test this assay in a more complex biological matrix, perchloric acid extracts of circulating human leukemia cells spiked with known concentrations of ara-GTP and F-ara-ATP were examined. "
03/01/2008 - "Pharmacokinetics of plasma nelarabine and arabinosylguanine (ara-G) and of cellular ara-G triphosphate (ara-GTP) were similar in the two groups of diagnoses, and the elimination of ara-GTP from leukemia cells was slow (median, > 24 hours). "
04/15/2001 - "The cellular pharmacokinetics was investigated to seek a relationship between response and accumulation of ara-G triphosphate (ara-GTP) in circulating leukemia cells and to evaluate biochemical modulation of cellular ara-GTP metabolism by fludarabine triphosphate. "
03/01/2008 - "Determination of tumor cell ara-GTP levels may provide a predictive test for response to nelarabine."
04/15/2001 - "Determination of ara-GTP levels in the target tumor population may provide a prognostic test for the activity of nelarabine."
02/01/2010 - "Because ara-GTP is crucial to ara-G's cytotoxicity, the determination of ara-GTP production in cancer cells is informative for optimizing nelarabine administration. "
|5.||Human Influenza (Influenza)
01/01/1989 - "The inhibitors modified only in 3'-ribose position did not express specificity to any of RNA-polymerases tested, while some analogues having two modification in the molecule demonstrated the selective inhibition of RNA-synthesis directed by the influenza A viral RNA-polymerase [ara GTP (3'NH2), RvTP (3'N3')]."
|2.||triphosphoric acid (triphosphate)
|5.||DNA-Directed RNA Polymerases (RNA Polymerase)
|6.||RNA (Ribonucleic Acid)
|8.||Perchloric Acid (Perchlorates)