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Ro 5-3663
RN given refers to parent cpd; structure in first source
Also Known As:
1,3-dihydro-5-methyl-2H-1,4-benzodiazepin-2-one; Ro 5-3663, monohydrochloride
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzazepines: 5
Benzodiazepines: 8452
Benzodiazepinones
Ro 5-3663: 4
Related Diseases
1.
Seizures (Absence Seizure)
03/23/1987 - "
Motor seizures were induced by Ro 5-3663 in 156 male albino rats aged 7,12,18,25, and 90 days.
"
10/01/1981 - "
Catalepsy and analgesia were found in varying degrees after maximal electroshock (MES), metrazol, picrotoxin, and Ro 5-3663 activated seizures.
"
10/01/1984 - "
PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole.
"
2.
Myoclonus (Nocturnal Myoclonus)
12/01/1984 - "
The quinolines, PK 8165, PK 9084 and CGS 8216 caused myoclonic jerks when combined with subconvulsant doses of Ro 5-3663 or picrotoxin; in combination with picrotoxin they also caused full tonic-clonic convulsions.
"
3.
Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic)
12/01/1984 - "
The quinolines, PK 8165, PK 9084 and CGS 8216 caused myoclonic jerks when combined with subconvulsant doses of Ro 5-3663 or picrotoxin; in combination with picrotoxin they also caused full tonic-clonic convulsions.
"
4.
Catalepsy
10/01/1981 - "
Catalepsy and analgesia were found in varying degrees after maximal electroshock (MES), metrazol, picrotoxin, and Ro 5-3663 activated seizures.
"
Related Drugs and Biologics
1.
Picrotoxin
2.
Pentylenetetrazole (Metrazol)
3.
Quinolines
4.
Convulsants
5.
Benzodiazepines
6.
PK 11195 (PK11195)
7.
2- phenylpyrazolo(4,3- c)quinolin- 3(5H)- one
8.
PK 9084
9.
pipequaline
Related Therapies and Procedures
1.
Analgesia