|1.||Zhang, Lei: 4 articles (07/2013 - 01/2012)|
|2.||Lu, Yin: 4 articles (07/2013 - 01/2012)|
|3.||Wu, Yu: 3 articles (07/2013 - 01/2012)|
|4.||Takeda, Shuso: 3 articles (03/2013 - 06/2011)|
|5.||Amamoto, Toshiaki: 3 articles (03/2013 - 06/2011)|
|6.||Okamoto, Yoshiko: 3 articles (03/2013 - 06/2011)|
|7.||Shindo, Mitsuru: 3 articles (03/2013 - 06/2011)|
|8.||Aramaki, Hironori: 3 articles (03/2013 - 06/2011)|
|9.||Tao, Li: 3 articles (01/2013 - 01/2012)|
|10.||Ruan, Junshan: 3 articles (01/2013 - 01/2012)|
06/01/2012 - "In conclusion, our results suggest that xanthatin may have therapeutic potential against human gastric carcinoma."
06/01/2012 - "In the present study, we demonstrated the significant antiproliferative and proapoptotic effects of xanthatin on human gastric carcinoma MKN-45 cells. "
06/01/2012 - "Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells."
01/01/2015 - "In this study, we described a novel VEGFR2 inhibitor, xanthatin, which inhibits tumor angiogenesis and growth. "
07/15/2013 - "Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. "
07/15/2013 - "We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. "
07/15/2013 - "Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. "
01/01/2013 - "Thus, the discovery of xanthatin, which has ability to simultaneously orchestrate two independent signaling cascades, may have important implications for screening promising drugs in cancer therapies. "
|3.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/01/2012 - "In this study, we demonstrated that xanthatin had obvious dose-/time-dependent cytotoxicity against the human non-small-cell lung cancer (NSCLC) cell line A549. "
01/01/2013 - "We found that disruption of GSK3β activity was essential for xanthatin to exert its anticancer properties in non-small cell lung cancer (NSCLC), concurrent with preferable suppression of constitutive activation of STAT3. "
01/01/2013 - "Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin."
01/01/2012 - "Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in A549 non-small-cell lung cancer cells."
|4.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Moreover, xanthatin directly inhibit proliferation of breast cancer cells MDA-MB-231. "
03/08/2013 - "Previously, we reported that (-)-xanthatin, a naturally occurring xanthanolide present in the Cocklebur plant, exhibits potent anti-proliferative effects on human breast cancer cells, accompanied by an induction of the growth arrest and DNA damage-inducible gene 45γ (GADD45γ), recognized recently as a novel tumor suppressor gene. "
01/01/2013 - "We reported that (-)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human breast cancer cells, in which GADD45γ, a novel tumor suppressor gene, was induced. "
06/20/2011 - "(--)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells."
01/01/2015 - "Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells."
|5.||Melanoma (Melanoma, Malignant)
07/15/2013 - "Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo."
07/15/2013 - "All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. "
04/01/2003 - "Two xanthanolide sesquiterpene lactones, 8- epi-xanthatin (1) and 8- epi-xanthatin epoxide (2), isolated from the leaves of Xanthium strumarium (Compositae), demonstrated a significant inhibition on the proliferation of cultured human tumor cells, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro. "
|2.||Etoposide (VP 16)
|4.||trioctyl phosphine oxide (TOPO)
|5.||Reactive Oxygen Species (Oxygen Radicals)
|6.||Messenger RNA (mRNA)
|7.||Prostaglandins E (PGE)
|10.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|1.||Heterologous Transplantation (Xenotransplantation)