|1.||Ohura, S: 1 article (05/2000)|
|2.||Murakami, A: 1 article (05/2000)|
|3.||Koshimizu, K: 1 article (05/2000)|
|4.||Toyota, K: 1 article (05/2000)|
|5.||Ohigashi, H: 1 article (05/2000)|
07/01/1994 - "Benzolactams become the simplest molecule reproducing the conformation and activity of teleocidin, and will be a useful tool for the study of tumor-promotion and cell differentiation."
05/01/2000 - "The structure-activity relationships of (1'S)-1'-acetoxychavicol acetate (ACA), a cancer chemopreventive agent of food origin, were investigated in an inhibitory test of tumor promoter teleocidin B-4-induced Epstein-Barr virus (EBV) activation in Raji cells. "
05/01/1998 - "Twist form of teleocidin derivatives is active in in vivo tumor promotion by (-)-benzolactam-V8-310."
04/01/1993 - "Despite the differences in response of C57BL/6 mice to TPA and teleocidin, this mouse strain was still highly resistant to skin tumor promotion by both types of promoters when compared with SENCAR mice. "
06/12/1992 - "Active conformation of a tumor promoter, teleocidin. "
12/01/1987 - "Interestingly, treatment of both strains of mice with multiple applications of teleocidin induced a marked epidermal hyperplasia, a high percentage of DCs and a high labeling index (LI), similar to that observed in DBA/2 mice 48 h after the last treatment. "
04/01/1993 - "In contrast, teleocidin was more effective than TPA on a molar basis for inducing sustained epidermal hyperplasia, approximately equi-effective for promoting skin tumors and significantly less effective for activating PKC isozymes in vitro when examined using C57BL/6 mice. "
04/01/1993 - "Teleocidin was less effective than TPA on a molar basis for inducing sustained epidermal hyperplasia, promoting skin tumors and activating partially purified epidermal PKC isozymes in vitro when examined using SENCAR mice. "
04/01/1993 - "Comparison of 12-O-tetradecanoylphorbol-13-acetate and teleocidin for induction of epidermal hyperplasia, activation of epidermal PKC isozymes and skin tumor promotion in SENCAR and C57BL/6 mice."
04/01/1993 - "The present study compared the ability of 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin to induce sustained epidermal hyperplasia, activate partially purified epidermal protein kinase C (PKC) isozymes and promote skin tumors in SENCAR and C57BL/6 mice. "
|3.||Myeloid Leukemia (Leukemia, Myelocytic)
12/01/1985 - "It is shown in the present study that treatments of the myeloid leukemia HL60 cells with various inducers of cell differentiation (dimethyl sulfoxide, retinoic acid, mezerein, 12-O-tetradecanoylphorbol-13-acetate, teleocidin) caused a dose-dependent reduction of the level of TaDNA transcripts, correlated with the diminution of c-myc transcripts. "
06/01/1991 - "The binding affinity order of synthetic analogs of teleocidin B correlated with the adhesion-inducing potency order of the compounds toward human leukemia cell line HL-60. "
01/01/1983 - "There was no direct correlation between teleocidin-responsiveness and Lyt-phenotypes of the leukemia cells."
01/01/1983 - "Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias."
12/15/1982 - "Three different diterpen polyols and the teleocidin have antileukemic effects on the human thymic leukemia cell line HPB-ALL by inducing phenotypic differentiation. "
01/01/1982 - "Induction of differentiation of human promyelocytic leukemia (HL-60) cells by teleocidin and phorbol-12-myristate-13-acetate."
|5.||Hepatocellular Carcinoma (Hepatoma)
05/15/1991 - "PLC/PRF/5 human hepatoma cells cultured with teleocidin reduced the rate of cell proliferation and were transformed into large cells with many vacuole-like subcellular structures. "
08/01/1982 - "The tumor promoter teleocidin inhibited the proliferation of human HUH hepatoma cells in tissue culture. "
08/01/1982 - "Effects of the tumor promoter teleocidin on human hepatoma cells in tissue culture."
07/30/1993 - "These inhibitory effects of teleocidin were observed even after a prolonged exposure of the hepatoma cells to this promoter, suggesting the presence of down-regulation-resistant protein kinase C in this hepatoma cell line. "
05/29/1987 - "Effects of teleocidin on the morphology and c-myc expression of hepatoma cells which are not inhibited by protein kinase antagonists."
|5.||Protein Kinase C
|10.||Tretinoin (Retinoic Acid)