HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
3,4-dihydroxybenzylamine
RN given refers to parent cpd; structure
Also Known As:
3,4-dihydroxybenzylamine hydrobromide; 3,4-dihydroxybenzylamine hydrochloride
Networked:
11
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Catecholamines: 15682
Dopamine: 23033
3,4-dihydroxybenzylamine: 11
Biogenic Amines: 992
Biogenic Monoamines: 29
Dopamine: 23033
3,4-dihydroxybenzylamine: 11
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Catechols: 121
Catecholamines: 15682
Dopamine: 23033
3,4-dihydroxybenzylamine: 11
Related Diseases
1.
Neoplasms (Cancer)
01/01/1990 - "
Tumor inhibition and hematological improvements by dopamine analog 3,4-dihydroxybenzylamine in mice bearing transplantable carcinoma.
"
01/01/1990 - "
The cancer chemotherapeutic efficacy of 3,4-dihydroxybenzylamine (DHBA), a dopamine analog with reduced neurotoxic effects, was evaluated in strain A mice bearing transplantable Ehrlich's ascites carcinoma.
"
06/01/1985 - "
A 4-hr exposure to 0.4 mM 3,4-dihydroxybenzylamine (DHBA), a compound which is melanolytic due to its conversion to a cytotoxic quinone by the tumor specific enzyme tyrosinase, was found to be approximately equitoxic to 2.5 mM DMFO.
"
2.
Carcinoma (Carcinomatosis)
01/01/1990 - "
Tumor inhibition and hematological improvements by dopamine analog 3,4-dihydroxybenzylamine in mice bearing transplantable carcinoma.
"
01/01/1990 - "
The cancer chemotherapeutic efficacy of 3,4-dihydroxybenzylamine (DHBA), a dopamine analog with reduced neurotoxic effects, was evaluated in strain A mice bearing transplantable Ehrlich's ascites carcinoma.
"
3.
Ascites
01/01/1990 - "
The cancer chemotherapeutic efficacy of 3,4-dihydroxybenzylamine (DHBA), a dopamine analog with reduced neurotoxic effects, was evaluated in strain A mice bearing transplantable Ehrlich's ascites carcinoma.
"
4.
Melanoma (Melanoma, Malignant)
09/15/1988 - "
3,4-Dihydroxybenzylamine was active in 3 of 8 melanomas and 1 of 5 nonmelanomas.
"
09/01/1992 - "
BSO enhanced 3,4-dihydroxybenzylamine (3,4-DHBA) (fourfold) and melphalan (threefold) in vitro cytotoxic activity as determined by inhibition of DNA synthesis in human melanoma cells and this enhancement was dependent on the duration of exposure to drug.
"
09/01/1992 - "
Melanoma cytotoxicity of buthionine sulfoximine (BSO) alone and in combination with 3,4-dihydroxybenzylamine and melphalan.
"
03/01/1990 - "
Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.
"
01/01/1989 - "
The toxicity and selectivity of 3,4-dihydroxybenzylamine (DHBA), an experimental antimelanoma agent that cannot enter the melanin pathway, broadly paralleled that of L-dopa in a panel of human melanoma cell lines sensitive or resistant to the latter drug.
"
5.
Experimental Melanoma
12/01/1979 - "
3,4-Dihydroxybenzylamine (DHBA), a dopamine analog, was much less toxic than dopamine when tested against the B16 melanoma in vivo and in vitro.
"
06/01/1985 - "
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
"
06/01/1983 - "
Several analogues have been prepared with significant antitumor activity against experimental melanoma models, and these include levodopa, dopamine, and the nonneurotoxic analogue 3,4-dihydroxybenzylamine.
"
Related Drugs and Biologics
1.
Dopamine (Intropin)
2.
Levodopa (L Dopa)
3.
Buthionine Sulfoximine
4.
Monophenol Monooxygenase (Tyrosinase)
5.
Nucleotides
6.
Norepinephrine (Noradrenaline)
7.
Methotrexate (Mexate)
8.
Melphalan (Alkeran)
9.
Melanins (Melanin)
10.
Lysophosphatidylcholines (Lysophosphatidylcholine)