changrolin

01/01/1996 - "Pharmacokinetic-pharmacodynamic analysis of changrolin in dogs with arrhythmia."
01/01/1996 - "The pharmacokinetics and pharmacodynamics of changrolin (CRL) were studied in 7 dogs with arrhythmia induced by coronary artery ligature. "
12/01/1983 - "[Effects of intravenous infusion of changrolin on cardiac function of patients with arrhythmia]."
09/01/1984 - "[Anti-arrhythmic effect of changrolin combined with nicotinamide in experimental arrhythmia]."
07/01/1979 - "[Antiarrhythmic effect of 4-(3',5'-bis ((n-pyrrolidinyl) methyl)-4'-hydroxyanilino) quinazoline (changrolin) on aconitine-induced arrhythmia in rats (author's transl)]."

10/01/1979 - "Intravenous injections in dogs and rabbits caused (i) a mild tachycardia followed by bradycardia; (ii) a prolongation of P-R interval and a widening of QRS complex in the electrocardiogram; (iii) a gradual hypotehsion; (iv) a slight weakening of cardiac functions; and (v) only moderate influences on the hearts of dogs and rabbits when the rate of infusion was less than 1 mg/min. Changrolin could be well absorbed by oral administration. "
09/01/1991 - "The indole-derived compounds, which possessed side chains resembling those of changrolin (4-[3',5'-bis[(N-pyrrolidinyl)methyl]-4'-hydroxyaniline]-quinazoline) showed potent anti-arrhythmic activity by restoration of sinus rhythm from ouabain-induced tachycardia in guinea pigs. "

10/01/1979 - "Intravenous injections in dogs and rabbits caused (i) a mild tachycardia followed by bradycardia; (ii) a prolongation of P-R interval and a widening of QRS complex in the electrocardiogram; (iii) a gradual hypotehsion; (iv) a slight weakening of cardiac functions; and (v) only moderate influences on the hearts of dogs and rabbits when the rate of infusion was less than 1 mg/min. Changrolin could be well absorbed by oral administration. "