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adrafinil (Olmifon)

induces hyperactivity

Also Known As:

Olmifon; CRL 40028; CRL-40028; adrafinyl; benzhydrylsulfinylacetohydroxamic acid; Acetamide, 2-((diphenylmethyl)sulfinyl)-N-hydroxy-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - adrafinil: 4
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - adrafinil: 4

Experts

1.	Ameline, Alice: 1 article (01/2020)
2.	Gheddar, Laurie: 1 article (01/2020)
3.	Kintz, Pascal: 1 article (01/2020)
4.	Raul, Jean-Sébastien: 1 article (01/2020)
5.	Benatru, Isabelle: 1 article (08/2004)
6.	Broussolle, Emmanuel: 1 article (08/2004)
7.	Mollion, Helena: 1 article (08/2004)
8.	Thobois, Stéphane: 1 article (08/2004)
9.	Xie, Jing: 1 article (08/2004)
10.	Gruet, P: 1 article (11/2000)

Related Diseases

1.	Dyskinesias (Dyskinesia) 08/01/2004 - "The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. " 08/01/2004 - "Adrafinil-induced orofacial dyskinesia." 08/01/2004 - "We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. "
2.	Mydriasis 01/01/1986 - "The following psychopharmacological effects of adrafinil have been observed in mice: increase in locomotor activity (64-256 mg.kg-1), antagonism (16-128 mg.kg-1) of the hypnotic effects of barbitone but not of pentobarbitone, reduction of immobility duration in the forced swimming test (16-256 mg.kg-1); slight antagonism (256 mg.kg-1) of electroshock-induced convulsions; no modification of rectal temperature; no stereotyped or climbing behaviour; no increase in lethality in aggregated mice (LD50 isolated = 1022 mg.kg-1, LD50 aggregated = 859 mg.kg-1); lack of effects on the provisional tests for antidepressants: no interaction with reserpine-, oxotremorine-, or apomorphine-induced hypothermia but potentiation of yohimbine-induced toxicity; lack of peripheral sympathetic effects (no mydriasis, no salivation, no contraction of the pilomotor muscles, no antagonism of reserpine-induced ptosis); lack of peripheral anticholinergic effects (no mydriasis, no antagonism of oxotremorine-induced salivation or lacrimation). "
3.	Narcolepsy 01/29/2020 - "Adrafinil, 2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. "
4.	Body Weight (Weight, Body) 11/01/2000 - "Dogs were randomly assigned to receive adrafinil (20 mg/kg of body weight, PO, q 24 h; n = 12), propentofylline (5 mg/kg, PO, q 12 h; 12), or nicergoline (0.5 mg/kg, PO, q 24 h; 12) for 33 days. "

Related Drugs and Biologics

1.	Cholinergic Antagonists (Anticholinergics)
2.	Yohimbine (Yocon)
3.	Reserpine (Serpasil)
4.	Pentobarbital (Nembutal)
5.	Oxotremorine
6.	Nicergoline
7.	Hypnotics and Sedatives (Sedatives)
8.	Barbital (Barbitone)
9.	Apomorphine
10.	Antidepressive Agents (Antidepressants)

Related Therapies and Procedures

1.	Induced Hypothermia