isofloxythepin

RN given refers to unlabeled cpd; structure

Also Known As:

3-fluor-8-isopropyl-10-(4-(2-hydroxyethyl)piperazino)-10,11-dihydrodibenzo(b,f)thiepin; isofloxythepin, 10-(14)C-labeled; 1-Piperazineethanol, 4-(3-fluoro-10,11-dihydro-8-(1-methylethyl)dibenzo(b,f)thiepin-10-yl)-

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiepins
    - Dibenzothiepins
      - isofloxythepin: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzothiepins
      - isofloxythepin: 5

Related Diseases

1.	Edema (Dropsy) 05/01/1989 - "Protection against the lethal effect of histamine and the inhibition of histamine edema by isofloxythepin may largely be due to mechanisms other than the blocking of H1-receptors." 05/01/1989 - "Isofloxythepin inhibited both the lethal effect of histamine injected i.v. in mice and histamine-induced edema in rat hind paws far more strongly than chlorpromazine or haloperidol did. "
2.	Decapitation 03/29/1988 - "The results imply that post-decapitation convulsions seem to be inhibited by a block of postsynaptic alpha 1-adrenoceptors, enhanced by a block of presynaptic alpha 2-adrenoceptors and reduced by isofloxythepin via the blocking of postsynaptic alpha 1-adrenoceptors. " 03/29/1988 - "Isofloxythepin (0.05-2.0 mg/kg s.c.) inhibited post-decapitation convulsions in a dose-dependent manner as shown by the decrease in the incidence and the shortening of the duration of convulsions. " 05/01/1986 - "Oral administration of isofloxythepin (0.5-8.0 mg/kg) inhibited decapitation convulsions in a dose-dependent manner as shown by decreasing the incidence and shortening the convulsion's duration, the effects continuing until 24 hr after administration. " 03/29/1988 - "The mechanisms involved in inhibitory effects of isofloxythepin, a newly synthesized dibenzothiepin neuroleptic, on post-decapitation convulsions were studied in rats. " 05/01/1986 - "Isofloxythepin at doses of 4 and 8 mg/kg, PO which completely abolished decapitation convulsions, failed to change norepinephrine and dopamine levels but increased serotonin levels in the spinal cord. "
3.	Psychotic Disorders (Schizoaffective Disorder) 04/01/1989 - "Controlled cross-over comparison of isofloxythepin and perphenazine in the treatment of schizophrenic psychoses."
4.	Catalepsy 02/01/1989 - "1. Subcutaneous injection of isofloxythepin or haloperidol inhibited exploratory behaviour, methamphetamine (3 mg/kg)-induced hyperactivity and bromocriptine (15 mg/kg)-induced yawning, and also elicited catalepsy. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Antipsychotic Agents (Antipsychotics)
3.	Haloperidol (Haldol)
4.	Serotonin (5 Hydroxytryptamine)
5.	Dopamine Receptors (Dopamine Receptor)
6.	Prolactin
7.	Perphenazine (Trilafon)
8.	Norepinephrine (Noradrenaline)
9.	Methamphetamine (Desoxyn)
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Oral Administration