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2-chloropropionic acid
RN given refers to parent cpd with specified chlorine locant; structure
Also Known As:
2-chloropropionate; 2-chloropropionic acid, (S)-isomer; 2-chloropropionic acid, sodium salt; sodium-2-chloropropionate; 2-chloropropanoic acid
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Chlorinated Hydrocarbons: 240
2-chloropropionic acid: 5
Carboxylic Acids: 973
Acyclic Acids
Propionates: 988
2-chloropropionic acid: 5
Lipids: 114793
Fatty Acids: 27405
Volatile Fatty Acids: 3052
Propionates: 988
2-chloropropionic acid: 5
Experts
1.
Camón, Lluïsa
: 1 article (05/2004)
2.
Martínez, Emili
: 1 article (05/2004)
3.
de Vera, Núria
: 1 article (05/2004)
Related Diseases
1.
Necrosis
01/01/1996 - "
Glutathione depletion in the liver and brain produced by 2-chloropropionic acid: relevance to cerebellar granule cell necrosis.
"
05/27/2004 - "
The neurotoxin 2-chloropropionic acid (2CPA, 750 mg/kg, per os) induces ataxia in rats causing neuropathological changes (necrosis and edema) localized mainly in the cerebellum (CB).
"
2.
Edema (Dropsy)
05/27/2004 - "
The neurotoxin 2-chloropropionic acid (2CPA, 750 mg/kg, per os) induces ataxia in rats causing neuropathological changes (necrosis and edema) localized mainly in the cerebellum (CB).
"
02/01/1991 - "
The pyruvate dehydrogenase stimulant sodium dichloroacetate (3.2 mM) on the tears side ameliorated the edema, and its congener, 3.2 mM 2-chloropropionate, was less effective.
"
3.
Hyperglycemia
06/01/1985 - "
We have previously shown that, in alloxan-diabetic dogs, the adjunction of sodium 2-chloropropionate (2-CP) with insulin injections resulted in a reduction of both hyperglycemia and hyperglucagonemia.
"
4.
Ataxia (Dyssynergia)
05/27/2004 - "
The neurotoxin 2-chloropropionic acid (2CPA, 750 mg/kg, per os) induces ataxia in rats causing neuropathological changes (necrosis and edema) localized mainly in the cerebellum (CB).
"
5.
Lactic Acidosis
01/01/1980 - "
Dichloroacetate, which decreases blood lactate very efficiently, has been sucessfully tested in the acute treatment of congenital lactic acidosis, but its transformation into oxalate and potential chronic toxicity prompt to replace it by 2-chloropropionate as a therapeutic agent.
"
Related Drugs and Biologics
1.
Lactic Acid (Lactate)
2.
Pyruvic Acid (Pyruvate)
3.
Sodium
4.
Oxidoreductases (Dehydrogenase)
5.
Oxalates
6.
Neurotoxins
7.
Insulin (Novolin)
8.
Glutathione (Reduced Glutathione)
9.
Dichloroacetic Acid
10.
Alloxan
Related Therapies and Procedures
1.
Injections