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4-oxalocrotonate tautomerase

sequence has been determined

Also Known As:

4-oxalocrotonate isomerase

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - 4-oxalocrotonate tautomerase: 2

Experts

1.	Geertsema, Edzard M: 1 article (06/2012)
2.	Poelarends, Gerrit J: 1 article (06/2012)
3.	Quax, Wim J: 1 article (06/2012)
4.	Zandvoort, Ellen: 1 article (06/2012)
5.	Fitzgerald, Michael C: 1 article (04/2002)
6.	Powell, Kendall D: 1 article (04/2002)
7.	Wales, Thomas E: 1 article (04/2002)

Related Diseases

1.	AIDS-Related Complex (ARC) 04/01/2002 - "Included in this work are the SUPREX results we obtained in studies on six model multimeric proteins including the GCN4p1 dimer, the coil-V(a)L(d) trimer, the 4-oxalocrotonate tautomerase (4-OT) hexamer, the Trp repressor (TrpR) dimer, the Arc repressor (ArcR) dimer, and an ArcR mutant (the (DOA20)ArcR) dimer which contained two destabilizing mutations including an Asp to Ala mutation at position 20 and an amide to ester bond mutation between amino acid (aa) residues 19 and 20. "
2.	Dehydration (Water Stress) 06/18/2012 - "Enhancement of the promiscuous aldolase and dehydration activities of 4-oxalocrotonate tautomerase by protein engineering." 06/18/2012 - "Double play: The enzyme 4-oxalocrotonate tautomerase (4-OT) catalyzes not only the initial cross-coupling of acetaldehyde and benzaldehyde to yield 3-hydroxy-3-phenylpropanal, but also the subsequent dehydration of this aldol compound to yield cinnamaldehyde as the final product. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Esters
3.	Amino Acids
4.	Amides
5.	E coli TRPR protein (Trp repressor)
6.	Fructose-Bisphosphate Aldolase (Aldolase)
7.	Enzymes
8.	Acetaldehyde
9.	3-hydroxybutanal (aldol)
10.	benzaldehyde