|1.||Sehested, Maxwell: 2 articles (04/2011 - 06/2010)|
|2.||Olesen, Uffe Høgh: 2 articles (04/2011 - 06/2010)|
|3.||Zhang, Yiyun: 1 article (12/2015)|
|4.||Flaherty, Keith T: 1 article (12/2015)|
|5.||Samuels, Yardena: 1 article (12/2015)|
|6.||Zhao, Dan: 1 article (12/2015)|
|7.||Lelic, Nina: 1 article (12/2015)|
|8.||Koerner, Mara V A: 1 article (12/2015)|
|9.||Deng, Gejing: 1 article (12/2015)|
|10.||Curry, William T: 1 article (12/2015)|
04/01/2011 - "Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas."
04/01/2011 - "The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), the primary, rate-limiting enzymes in the synthesis of NAD+. NAMPT is a potential biomarker for sensitivity to NAMPT inhibitors and NAPRT is a biomarker for the use of nicotinic acid as a chemoprotectant in treatment with NAMPT inhibitors. "
12/14/2015 - "To identify other metabolic therapeutic targets, we systematically profiled metabolites in endogenous IDH1 mutant cancer cells after mutant IDH1 inhibition and discovered a profound vulnerability to depletion of the coenzyme NAD+. Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition. "
11/01/2009 - "The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors."
06/01/2010 - "In conclusion, the combination of high doses of APO866 with rescue by nicotinic acid may significantly increase the therapeutic potential in a subset of cancers with low expression of nicotinic acid phosphoribosyltransferase."
|2.||Niacin (Nicotinic Acid)
|4.||N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamide
|5.||N- (6- chlorophenoxyhexyl)- N''- cyano- N''- 4- pyridylguanidine (CHS 828)