formyl- methenyl- methylenetetrahydrofolate synthetase

trifunctional enzyme which contains EC 6.3.4.3, formyltetrahydrofolate synthetase, plus EC 3.5.4.9, methenyltetrahydrofolate cyclohydrolase, and EC 1.5.1.5, methylenetetrahydrofolate dehydrogenase as a complex in sheep liver

Also Known As:

C-1-tetrahydrofolate synthetase; C1-THF synthase; C1-tetrahydrofolate synthase; MTHFD1 protein; MTHFD1L protein; NADP-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase; formyl-methenyl-methylenetetrahydrofolate synthetase (combined); trifunctional MTHFD1 protein; Synthetase, formyl-methenyl-methylenetetrahydrofolate

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lin, David M: 1 article (03/2011)
2.	MacFarlane, Amanda J: 1 article (03/2011)
3.	McEntee, Michael F: 1 article (03/2011)
4.	Perry, Cheryll A: 1 article (03/2011)
5.	Stover, Patrick J: 1 article (03/2011)
6.	Fountoulakis, M: 1 article (01/2003)
7.	Gulesserian, T: 1 article (01/2003)
8.	Lubec, G: 1 article (01/2003)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2023 - "Our results uncovered an unidentified mechanism underlying of the impact of G1958A SNP on MTHFD1 protein stability and tumor metabolism in HCC. " 03/01/2011 - "In this study, we use Mthfd1(gt/+) mice, which demonstrate a 50% reduction in C1-tetrahydrofolate synthase, to determine its influence on tumor development in two mouse models of intestinal cancer, crosses between Mthfd1(gt/+) and Apc(min)(/+) mice and azoxymethane (AOM)-induced colon cancer in Mthfd1(gt/+) mice. "
2.	Intestinal Neoplasms (Intestinal Cancer) 03/01/2011 - "In this study, we use Mthfd1(gt/+) mice, which demonstrate a 50% reduction in C1-tetrahydrofolate synthase, to determine its influence on tumor development in two mouse models of intestinal cancer, crosses between Mthfd1(gt/+) and Apc(min)(/+) mice and azoxymethane (AOM)-induced colon cancer in Mthfd1(gt/+) mice. "
3.	Colonic Neoplasms (Colon Cancer) 03/01/2011 - "In this study, we use Mthfd1(gt/+) mice, which demonstrate a 50% reduction in C1-tetrahydrofolate synthase, to determine its influence on tumor development in two mouse models of intestinal cancer, crosses between Mthfd1(gt/+) and Apc(min)(/+) mice and azoxymethane (AOM)-induced colon cancer in Mthfd1(gt/+) mice. "
4.	Chromosomal Instability (Chromosome Stability) 08/01/1994 - "A hypothesis implicating a candidate gene, C1-THF synthase, in the generation of chromosome instability in the pathogenesis of familial Alzheimer's disease, is presented."
5.	Down Syndrome (Down's Syndrome) 01/01/2003 - "Overexpression of C1-tetrahydrofolate synthase in fetal Down syndrome brain."

Related Drugs and Biologics

1.	Azoxymethane