2-tetradecylglycidic acid

structure

Also Known As:

2-tetradecylglycidic acid, (+-)-isomer; 2-tetradecylglycidic acid, (R)-isomer; 2-tetradecylglycidic acid, (S)-isomer; 2-tetradecyloxiranecarboxylic acid; McN-3802; palmoxiric acid

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - 2-tetradecylglycidic acid: 4
Lipids: 114793
- Fatty Acids: 27405
  - 2-tetradecylglycidic acid: 4

Related Diseases

1.	Hypertrophy 08/01/1999 - "2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor." 10/01/1991 - "To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction. " 08/01/1999 - "This study tested the hypothesis that 2-tetradecylglycidic acid (TDGA), an oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor system. " 09/01/1993 - "Studies from our laboratories have previously shown that 2-tetradecylglycidic acid, an inhibitor of carnitine palmitoyl transferase I, inhibits mitochondrial long-chain fatty acid oxidation and causes myocardial hypertrophy when given to rats by mouth for 7-28 days. "
2.	Infarction (Infarctions) 10/01/1991 - "To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction. "
3.	Body Weight (Weight, Body) 12/15/1984 - "The effect of body weight and the fatty acid-oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in mouse heart."

Related Drugs and Biologics

1.	Carnitine (L-Carnitine)
2.	Fatty Acids (Saturated Fatty Acids)
3.	Transferases
4.	Ethylene Oxide (Oxirane)
5.	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
6.	salicylhydroxamic acid (SHAM)