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lodoxamide ethyl (lodoxamide)

inhibits anaphylactic reactions; structure
Also Known As:
lodoxamide; U-42,718; diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate; 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxoacetic acid), diethyl ester
Networked: 52 relevant articles (18 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Alam, Raffique: 1 article (03/2011)
2. Khan, Moosa: 1 article (03/2011)
3. Gul, Ali: 1 article (03/2011)
4. Das, Dial: 1 article (03/2011)
5. Akova, Yonca A: 1 article (09/2006)
6. Gedik, Sansal: 1 article (09/2006)
7. Gür, Sirel: 1 article (09/2006)
8. Onakoya, A O: 1 article (03/2006)
9. Olasimbo, O O: 1 article (03/2006)
10. Adefule, A K: 1 article (03/2006)

Related Diseases

1. Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
2. Hypersensitivity (Allergy)
3. Eye Diseases (Eye Disease)
4. Bronchial Spasm
5. Pruritus (Itching)
09/01/1997 - "The results, obtained by evaluating the main clinical signs and symptoms (itching, lacrimation, hyperaemia, palpebral oedema and chemosis), demonstrate with statistically significant differences that lodoxamide inhibits the conjunctival response to exposure to the allergen with greater efficacy than spaglumic acid, and for a longer duration. "
01/01/1996 - "Statistically significant trends toward improvement were noted in the lodoxamide group in resolving papillae on day 30, decreasing corneal staining on days 30 and 60, relieving photophobia on day 60, tearing on days 7, 30 and 60 and itching on days 30 and 60. "
05/01/1997 - "Lodoxamide significantly reduced tryptase levels (P < 0.01), neutrophils (P < 0.04), and eosinophils (P < 0.01) in the tear fluid and significantly inhibited ocular itching (P < 0.02) when compared with that of placebo. "
04/01/2001 - "However, relative to levocabastine, conjunctival discharge, photophobia and lacrimation were significantly reduced by lodoxamide at months 1, 2 and 3, itching at months 2 and 3, and bulbar conjunctiva at month 3. The temporal improvement of superior tarsal papillae did not differ significantly between treatments. "
06/15/1992 - "On various follow-up visits, the clinical efficacy of lodoxamide 0.1% was statistically superior to cromolyn sodium 4% in alleviating four of the primary symptoms (itching, tearing, foreign-body sensation, and discomfort) and five of the primary signs (Trantas' dots, palpebral conjunctival changes, bulbar conjunctival hyperemia, erythema/swelling of the eyelids and periorbital tissues, and epithelial disease). "

Related Drugs and Biologics

1. Cromolyn Sodium (Cromoglicic Acid)
2. Ophthalmic Solutions (Eye Drops)
3. Antigens
4. levocabastine (Bilina)
5. N-acetyl-1-aspartylglutamic acid (NAAGA)
6. Lubricants
7. Eosinophil Cationic Protein
8. Histamine (Histamine Dihydrochloride)
9. p-Methoxy-N-methylphenethylamine
10. Leukotriene C4

Related Therapies and Procedures

1. Artificial Eye (Artificial Eyes)
2. Topical Administration