dihydrolipoamide succinyltransferase

component of the ketoglutarate dehydrogenase complex; do not confuse with E2 enzymes of pyruvate dehydrogenase (PDC) and branched-chain 2-oxoacid dehydrogenase complexes; RefSeq NM_001006981 (DLST protein, rat)

Also Known As:

DLST protein, rat; OGDC-E2; dihydrolipoyl transsuccinylase; lipoamide succinyltransferase; lipoate succinyltransferase; lipoyl transsuccinylase; succinyl-CoA-dihydrolipoate-S-succinyltransferase; succinyl-coenzyme A-dihydrolipoate-S-succinyltransferase

Networked: 17 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - dihydrolipoamide succinyltransferase: 17

Experts

1.	Chen, Jin-wei: 1 article (04/2012)
2.	Li, Fen: 1 article (04/2012)
3.	Liu, Yi-ming: 1 article (04/2012)
4.	Xiao, Hua: 1 article (04/2012)
5.	Xie, Xi: 1 article (04/2012)
6.	Ohsawa, Ikuroh: 1 article (07/2006)
7.	Ohta, Shigeo: 1 article (07/2006)
8.	Anthony, N B: 1 article (05/2005)
9.	Balog, J M: 1 article (05/2005)
10.	Cisar, C R: 1 article (05/2005)

Related Diseases

1.	Ascites 05/01/2005 - "Both mitochondrial matrix proteins, the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex and the alpha-subunit of mitochondrial trifunctional enzyme, were present at higher levels in ascites-resistant line broilers with ascites in the present study. "
2.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 05/01/2003 - "Promiscuous T cells selected by Escherichia coli: OGDC-E2 in primary biliary cirrhosis." 06/01/1990 - "In this report, we confirm that primary biliary cirrhosis sera react with dihydrolipoamide succinyltransferase, the E2 component of alpha-ketoglutarate dehydrogenase complex. " 10/01/2001 - "The major autoantigens to anti-mitochondrial antibody (AMA) in primary biliary cirrhosis (PBC) have previously been identified to be PDC-E2, BCOADC-E2, and OGDC-E2. " 06/01/1998 - "The porcine PDC-E2 and the dihydrolipoamide succinyltransferase (OGDC-E2) component of the porcine 2-oxoglutarate dehydrogenase complex (OGDC) were identified as mitochondrial autoantigen with sera from patients with primary biliary cirrhosis (PBC). " 06/01/1990 - "Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis."
3.	Alzheimer Disease (Alzheimer's Disease) 02/20/1996 - "We have demonstrated that three genes (dihydrolipoamide succinyltransferase, S31iii125, and S20i15), which are linked to FOS in the familial Alzheimer disease focus (AD3) on human chromosome 14, have homologues in the Fugu genome adjacent to Fugu cFOS. " 08/15/1994 - "In addition, a possible relationship between dihydrolipoamide succinyltransferase and familial Alzheimer's disease is discussed." 10/29/1993 - "Abnormality of the dihydrolipoamide succinyltransferase gene may be a cause of familial Alzheimer's disease linked to chromosome 14q24.3. However, the locus of the dihydrolipoamide succinyltransferase gene on this chromosome was uncertain. " 07/01/2006 - "Large-scale epidemiological case-control studies suggest the involvements of dihydrolipoamide succinyltransferase (DLST) of the mitochondrial Krebs cycle and mitochondrial aldehyde dehydrogenase-2 (ALDH2) in Alzheimer's disease (AD). " 10/25/2001 - "To investigate the association between the polymorphic alleles of dihydrolipoamide succinyltransferase (DLST) gene cDNA at position A19117G in intron 13 and C19183T in exon 14 and the risk for sporandic Alzheimer's disease (SAD). "
4.	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 03/01/1996 - "To determine whether an enzyme abnormality occurs in brain, we measured immunoreactive levels of the three alpha KGDHC subunits, namely, alpha-ketoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and E3 in postmortem frontal, occipital and cerebellar cortices of 18 control subjects, 9 patients with FA and, for comparison, 12 patients with spinocerebellar ataxia type 1 (SCA1). "
5.	Leukemia 04/18/2012 - "A anti-mitochondrial antibodies-M2(AMA-M2), anti-BCOADC-E2 PDC-E2 OGDC-E2 antibodies (anti-3E/BPO), anti-SP100 antibodies (anti-SP100), anti-promyelocytic leukemia (anti-PML), anti-gp210 antibodies (anti-gp210),and anti-Ro-52 were detected respectively in 330 suspected PBC cases by Western blotting. "

Related Drugs and Biologics

1.	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)
2.	Proteins (Proteins, Gene)
3.	Enzymes
4.	dihydrolipoamide acyltransferase
5.	Autoantigens
6.	Autoantibodies
7.	Antigens
8.	Complementary DNA (cDNA)
9.	Nucleic Acids
10.	Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)