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glycerophosphoinositol glycerophosphodiesterase

Also Known As:

glycero(3)phosphoinositol glycerophosphohydrolase; glycerophosphoinositol phosphodiesterase; phosphoinositidase C; phosphoinositidase C beta

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        glycerophosphoinositol glycerophosphodiesterase: 14

Related Diseases

1.	Neuroblastoma 03/01/1995 - "Measurement of the intracellular Ca2+ concentration ([Ca2+]i) in fura-2-loaded single cells of the human neuroblastoma line SH-SY5Y indicated coexpression of muscarinic and bradykinin receptors linked to activation of phosphoinositidase C (PIC). " 02/01/1990 - "Regulation of muscarinic agonist-induced activation of phosphoinositidase C in electrically permeabilized SH-SY5Y human neuroblastoma cells by guanine nucleotides." 11/07/1993 - "Membranes of a variety of clonal cell lines, including neuroblastoma x glioma hybrid NG108-15, glioma C6, Rat 1 and CHO fibroblasts and the pituitary-derived cell lines alpha T3 and GH3 were immunoblotted with an antiserum (CQ) raised against a synthetic peptide corresponding to the C-terminal decapeptide of the alpha subunits of the phosphoinositidase-C-linked G-proteins Gq and G11. "
2.	Burkitt Lymphoma (Burkitt's Lymphoma) 12/01/1994 - "The modulation of phosphoinositidase C (PIC) beta activity upon interferon treatment in Burkitt lymphoma cells (Daudi) and its localization and expression have been analyzed by Western blotting, immunocytochemical and immunoelectronmicroscopy analysis. " 05/01/1993 - "Evidence for nuclear phosphoinositidase C activity in the antiproliferative signals produced by interferon in Burkitt lymphoma cells." 02/01/1995 - "Phosphoinositidase C beta 1 isoform expression is modulated by interferon alpha in Burkitt lymphoma cells." 02/01/1995 - "The expression of phosphoinositidase C (PIC) at nuclear and cytoplasmic level has been revealed in control and interferon treated Burkitt lymphoma cells by means of western blotting and immunocytochemical analysis employing specific monoclonal antibodies against beta 1, gamma 1 and delta 1 isozymes. "
3.	Pheochromocytoma 08/31/1992 - "Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells." 08/01/1993 - "The rat pheochromocytoma PC12 cell line, which differentiates into sympathetic neurons under nerve growth factor (NGF) treatment, contains at least three phosphoinositidase C (PIC) isozymes, PIC beta, PIC gamma, PIC delta. " 08/31/1992 - "Phosphoinositidase C activity was revealed in nuclei isolated from PC12 rat pheochromocytoma cells incubated with tritiated phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. "
4.	Vesicular Stomatitis 10/01/1989 - "A monospecific inhibitory antibody directed to phospholipase C (phosphoinositidase C) blocked the antiviral effect of human interferons alpha and beta when tested on human quiescent fibroblasts challenged with the vesicular stomatitis virus. "
5.	Whooping Cough (Pertussis) 05/01/1993 - "These data suggest that whereas ligands in fetal calf serum activate [3H]arachidonic acid release largely directly via the action of a pertussis-sensitive G protein, activation of phosphoinositidase C is indirect, being substantially dependent upon eicosanoid production. "

Related Drugs and Biologics

1.	Interferons
2.	GTP-Binding Proteins (G-Protein)
3.	Isoenzymes
4.	Nerve Growth Factor (NGF)
5.	Protein Isoforms (Isoforms)
6.	Muscarinic Agonists
7.	Cholinergic Agents (Cholinergics)
8.	Bradykinin Receptors (Bradykinin Receptor)
9.	Interferon-alpha (Interferon Alfa)
10.	Arachidonic Acid (Vitamin F)