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IMP cyclohydrolase

Also Known As:

inosinicase

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Aminohydrolases: 1
      - Nucleotide Deaminases
        IMP cyclohydrolase: 14

Experts

1.	Deng, Xianchao: 1 article (12/2022)
2.	Wang, Fang: 1 article (12/2022)
3.	Wang, Yuehua: 1 article (12/2022)
4.	Wu, Bin: 1 article (12/2022)
5.	Wu, Wangwei: 1 article (12/2022)
6.	Gui, Ying: 1 article (09/2022)
7.	Hu, Zuojian: 1 article (09/2022)
8.	Huang, Chunni: 1 article (09/2022)
9.	Li, Ruolin: 1 article (09/2022)
10.	Ling, Zhian: 1 article (09/2022)

Related Diseases

1.	Multiple Myeloma 09/01/2022 - "5-Amino-4-Imidazolecarboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase Polymorphisms Affect the Susceptibility to Multiple Myeloma." 09/01/2022 - "The upregulation of 5-amino-4-imidazolecarboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC) may affect tumorigenesis and multiple myeloma (MM) development. " 12/01/2022 - "Circular RNA (circRNA) 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (circATIC; hsa_circ_0058058) was observed to be upregulated in multiple myeloma (MM) by former article. " 06/01/2021 - "The role of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) has not yet been well studied in the area of MM. Thus, in the current study, we sought to examine the expression levels, including mRNA and protein levels of ATIC in MM. Multiple myeloma microarray and RNA-seq data were screened from the SRA, GEO, ArrayExpress, and Oncomine databases. "
2.	Neoplasms (Cancer) 01/01/2021 - "Based on the results of multivariate Cox regression analysis, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate (IMP) cyclohydrolase (ATIC) had the largest hazard ratio, and thus we studied the effect of ATIC on autophagy and tumor progression by performing in vitro and in vivo experiments. " 09/01/2004 - "We identified the following three genes coding for proliferation-related proteins: thymidylate synthase (TYMS), which is involved in chemoresistance (5-fluorouracil); 5'-aminoimidazole-4-carboxamide-1-beta-d-ribonucleotide transfolmylase/inosinicase (AICRT/I); and phosphoglycerate kinase 1 (PKG1), which was secreted by tumor cells and involved in the angiogenic process. " 01/01/2005 - "In most of these tumors, the t(2;5)(p23;q35) translocation causes fusion of the ALK gene to the 5' region of the nucleophosmin (NPM) gene, but other different ALK partners have been identified, including nonmuscle tropomyosin (TPM3), TRK-fused gene (TFG), 5' aminoimidazole-4-carboxamide ribonucleotide formyltranferase/IMP cyclohydrolase (ATIC), clathrin heavy chain gene (CLTC), and moesin (MSN). "
3.	Carcinoma (Carcinomatosis) 06/01/1975 - "[IMP-cyclohydrolase/transformylase from ehrlich-ascites carcinoma (author's transl)]." 01/01/2023 - "MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase."
4.	Carcinogenesis 09/01/2022 - "The upregulation of 5-amino-4-imidazolecarboxamide ribonucleotide transformylase/IMP cyclohydrolase (ATIC) may affect tumorigenesis and multiple myeloma (MM) development. "
5.	Neurologic Manifestations (Neurological Manifestations) 02/01/2010 - "The deficiency of adenylosuccinate lyase and 5-amino-4-imidazolecarboxamide ribotide transformylase/IMP cyclohydrolase, both belonging to the de novo purine synthesis pathway, is also associated to severe neurological manifestations. "

Related Drugs and Biologics

1.	Hydroxymethyl and Formyl Transferases
2.	Ribonucleotides
3.	Proteins (Proteins, Gene)
4.	Messenger RNA (mRNA)
5.	RNA (Ribonucleic Acid)
6.	purine
7.	Enzymes
8.	Phosphoribosylaminoimidazolecarboxamide Formyltransferase
9.	Adenylosuccinate Lyase
10.	Clathrin Heavy Chains