|1.||Cross, Heide S: 12 articles (06/2008 - 06/2002)|
|2.||Kállay, Enikö: 6 articles (10/2014 - 06/2002)|
|3.||Johnson, Candace S: 6 articles (07/2013 - 07/2006)|
|4.||Trump, Donald L: 6 articles (07/2013 - 07/2006)|
|5.||Lechner, Daniel: 6 articles (03/2007 - 12/2003)|
|6.||Petkovich, Martin: 5 articles (05/2012 - 10/2006)|
|7.||Hershberger, Pamela A: 4 articles (07/2013 - 10/2006)|
|8.||Manhardt, Teresa: 4 articles (07/2013 - 06/2002)|
|9.||Kanterewicz, Beatriz: 4 articles (07/2013 - 10/2006)|
|10.||Peng, Xinjian: 4 articles (02/2012 - 07/2006)|
10/01/2009 - "In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24, which serves as a possible mechanism for the high CYP24 expression in cancer tissues."
05/15/2012 - "Human lung tumors aberrantly express the 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-catabolizing enzyme, CYP24. "
03/23/2007 - "CYP24 promoter hypermethylation was also observed in endothelial cells isolated from other tumors but not in endothelial cells isolated from normal mouse tissues. "
03/01/2007 - "A different pattern of SNPs was identified at positions 24, 46, 146 and 198 in the intron between exons 9 and 10 of CYP24 gene in each cancer cell line. "
10/15/2006 - "Tumor-specific CYP24 upregulation was confirmed at the protein level via immunoblot analysis of patient-matched normal lung tissue and lung tumor extracts. "
|2.||Prostatic Neoplasms (Prostate Cancer)
05/01/2004 - "The high concentration of 50 micromol/L is very effective in eliminating CYP24 expression in prostate cancer cells. "
05/15/2005 - "5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells."
09/25/2002 - "High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. "
03/01/2007 - "We have investigated, in human PC3, DU145 and LNCaP prostate cancer cell lines, the relationship of CYP24 single nucleotide polymorphisms (SNPs) and splicing and the variable patterns of baseline and calcitriol-inducible CYP24 activity. "
03/01/2007 - "CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines."
|3.||Lung Neoplasms (Lung Cancer)
05/15/2012 - "We hypothesized that CYP24 reduces 1,25(OH)(2)D(3)-mediated transcription and allows lung cancer cells to escape its growth-inhibitory action. "
05/15/2012 - "CYP24 inhibition preserves 1α,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells."
01/01/2012 - "1alpha,25-Dihydroxyvitamin D3 has an inhibitory effect on the proliferation of cancer tissues, and is converted to its inactive 24-hydroxylated derivatives by CYP24, which is frequently expressed in lung cancer tissues. "
10/15/2006 - "These data suggest that increased CYP24 expression in lung tumors restricts 1,25D3 activity and support the preclinical evaluation of CYP24 inhibitors for lung cancer treatment."
07/01/2013 - "To ascertain the basis for CYP24 dysregulation, we assembled a panel of cell lines that represent distinct molecular classes of lung cancer: cell lines were selected which harbored mutually exclusive mutations in either the K-ras or the Epidermal Growth Factor Receptor (EGFR) genes. "
|4.||Colonic Neoplasms (Colon Cancer)
07/01/2013 - "Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells."
02/01/2012 - "Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D₃ in human colon cancer cells."
05/01/2013 - "In this study, we tested whether these compounds regulated two important VDR target genes - human cathelicidin antimicrobial peptide (CAMP) and 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) - in human monocytic cell line U937, colon cancer cell line HT-29 and keratinocyte cell line HaCaT. "
02/01/2012 - "In this study, we investigated the functional significance of 1,25(OH)₂D₃ in CYP24 RNA splicing in colon cancer cells. "
10/01/2006 - "The presence of 9-cis-RA increases induction of cyp24 transcripts and differentiation of colon cancer cells by vitamin D, confers significant agonistic activity to a VDR ligand with very low agonistic activity and can even restore transcriptional activity of an AF-2 mutant VDR that causes hereditary rickets. "
|5.||Breast Neoplasms (Breast Cancer)
09/01/2010 - "Functionality of unliganded VDR in breast cancer cells: repressive action on CYP24 basal transcription."
10/01/2009 - "It is noteworthy that the CYP24 protein levels in cancer tissues were inversely associated with the cancer/normal ratios of the miR-125b levels, indicating that the decreased miR-125b levels in breast cancer tissues would be one of the causes of the high CYP24 protein expression. "
09/01/2010 - "This study is focused on the functional role of unliganded VDR by investigating the correlation between the expression of VDR protein and basal mRNA levels of CYP24 in breast cancer cell lines. "
09/01/2010 - "Analyses of multiple breast cancer cell lines demonstrated an inverse correlation between VDR protein expression and CYP24 mRNA expression levels; while in the presence of ligand, VDR protein level was positively correlated with CYP24 expression. "
10/01/2009 - "Immunohistochemical analysis revealed that the CYP24 protein levels in human breast cancer were higher than in adjacent normal tissues, without an accompanying CYP24 mRNA increase. "
|3.||Messenger RNA (mRNA)
|5.||25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)
|6.||Calcitriol Receptors (Calcitriol Receptor)
|9.||DNA (Deoxyribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)