vitamin D 24-hydroxylase (CYP24)

Subscribe to Selected New Research on vitamin D 24-hydroxylase

51 relevant articles (2 outcomes, 4 trials/studies) found for this Bio-Agent

Description: catabolism of 1,25-(OH)2D3 in target tissues occurs through hydroxylation at either C-23 or C-24; 23- and 24-hydroxylase activities have been shown to co-localize with the same cytochrome P450, CYP24

Also Known As:

CYP24; 1 alpha,25-dihydroxycholecalciferol-24-hydroxylase; 1 alpha,25-dihydroxyvitamin D(3)-24-hydroxylase; 1,25-DC-24-hydroxylase; 1,25-dihydroxyvitamin D3 24-hydroxylase; 24-hydroxylase cytochrome P-450; 25(OH)vitamin D-24-hydroxylase; 25-HC-24-hydroxylase; 25-OH-D3 23-hydroxylase; 25-hydroxy vitamin D2 24-hydroxylase; 25-hydroxycholecalciferol 23-hydroxylase; 25-hydroxycholecalciferol-24-hydroxylase; 25-hydroxyvitamin D 23-hydroxylase; 25-hydroxyvitamin D(3)-24-hydroxylase; 25-hydroxyvitamin D(3)-24R-hydroxylase; 25-hydroxyvitamin D3 23-hydroxylase; calcitriol 24-hydroxylase; cytochrome P450(24); cytochrome P450c24; cytochrome P450cc24; vitamin D-24-hydroxylase

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Trump, Donald L: 2 articles (03/2007 - 03/2007)
2.	Johnson, Candace S: 2 articles (03/2007 - 03/2007)
3.	Muindi, Josephia R: 2 articles (03/2007 - 03/2007)
4.	Brunet, Andrea H: 1 article (08/2007)
5.	Acosta, Anna: 1 article (08/2007)
6.	Valrance, Meggan E: 1 article (08/2007)
7.	Welsh, Joellen: 1 article (08/2007)
8.	Noack, Frank: 1 article (07/2007)
9.	Diedrich, Klaus: 1 article (07/2007)
10.	Taylor, Robert N: 1 article (07/2007)

Related Diseases

1.	Neoplasms (Cancer) 03/23/2007 - "CYP24 promoter hypermethylation was also observed in endothelial cells isolated from other tumors but not in endothelial cells isolated from normal mouse tissues" 03/01/2007 - "A different pattern of SNPs was identified at positions 24, 46, 146 and 198 in the intron between exons 9 and 10 of CYP24 gene in each cancer cell line" 10/15/2006 - "Tumor-specific CYP24 upregulation was confirmed at the protein level via immunoblot analysis of patient-matched normal lung tissue and lung tumor extracts" 10/15/2006 - "CYP24 expression by RT-PCR was also detected in 10/18 primary lung tumors but in only 1/11 normal lung tissue specimens" 12/01/2007 - "Although the amount of total CYP24 decreases slightly in CRC as a function of tumor cell dedifferentiation and metastasis, location of this enzyme shifts almost entirely from the nuclear compartment to the cytoplasmic compartment" Get all the results and reference details, order at left...
2.	Prostatic Neoplasms (Prostate Cancer) 05/01/2004 - "The high concentration of 50 micromol/L is very effective in eliminating CYP24 expression in prostate cancer cells" 05/15/2005 - "5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells." 09/25/2002 - "High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite" 03/01/2007 - "We have investigated, in human PC3, DU145 and LNCaP prostate cancer cell lines, the relationship of CYP24 single nucleotide polymorphisms (SNPs) and splicing and the variable patterns of baseline and calcitriol-inducible CYP24 activity" 03/01/2007 - "CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines." Get all the results and reference details, order at left...
3.	Carcinoma (Carcinomatosis) 06/10/2002 - "In the present study we addressed the question of whether the effects of epidermal growth factor (EGF) and of 1,25-D3 on VDR, CYP27B1, and CYP24 gene expression in human colon carcinoma cell lines also depend on the degree of cellular differentiation" 06/10/2002 - "Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3)." 03/08/2001 - "This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1)" 07/01/1999 - "Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas." 06/10/2002 - "Human colon carcinoma cells express 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and thus produce the vitamin D receptor (VDR) ligand 1alpha,25-dihydroxyvitamin D(3) (1,25-D3), which can be metabolized by 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24)" Get all the results and reference details, order at left...
4.	Breast Neoplasms (Breast Cancer) 05/01/2004 - "We applied the chromatin immunoprecipitation (ChIP) method for the analysis of 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3))-dependent chromatin activity on the human 24-hydroxylase (CYP24) promoter in MCF-7 human breast cancer cells" 02/01/2004 - "BACKGROUND: By using array comparative genomic hybridization (CGH), the increased copy number of CYP24 (which encodes vitamin D 24-hydroxylase) at 20q13.2 was previously reported, leading to the identification of CYP24 as a candidate oncogene in breast cancer" 11/01/2006 - "QW also blocked the sustained induction of CYP24 expression by 1,25(OH)(2)D(3) and EB 1089, increased the potency of 1,25(OH)(2)D(3) and EB 1089, and inhibited breast tumor cell proliferation and invasion." 07/15/2006 - "This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, which is involved in the antiproliferative action of vitamin D without affecting CYP24 transactivation in breast cancer cells." 07/01/2006 - "MRNA expression of CYP271b and the 1,25(OH)2D3 inactivating enzyme CYP24 were measured in breast cancer cell lines by RT-PCR and correlated with immunoblotting approaches to the translated proteins" Get all the results and reference details, order at left...
5.	Osteosarcoma (Osteogenic Sarcoma) 03/01/2007 - "RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells." 03/15/2000 - "We evaluated the biological activity of two sets of ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2-methyl-1alpha,25(OH)(2)D(3)) and 2-methyl-20-epi-1alpha, 25-dihydroxyvitamin D(3) (2-methyl-20-epi-1alpha,25(OH)(2)D(3)) in terms of the following: transactivation of a rat 25-hydroxyvitamin D(3)-24-hydroxylase gene promoter including two vitamin D response elements (VDREs) and a human osteocalcin gene promoter including a VDRE in transfected human osteosarcoma (MG-63) cells; a vitamin D receptor (VDR)-mediated response using a VDR-GAL4 one-hybrid luciferase reporter system and a retinoid X receptor alpha (RXRalpha)-mediated response using an expressed VDR/RXRalpha-GAL4 modified two-hybrid luciferase reporter system in transfected human epitheloid carcinoma, cervix (HeLa) cells; and modulation of cell surface CD11b antigen expression in human leukemia (HL-60) cells" Get all the results and reference details, order at left...
23 Diseases and 51