|1.||Itano, Naoki: 9 articles (09/2014 - 01/2004)|
|2.||Kimata, Koji: 8 articles (01/2011 - 01/2004)|
|3.||Pilarski, Linda M: 7 articles (01/2014 - 03/2005)|
|4.||Heldin, Paraskevi: 6 articles (08/2014 - 11/2002)|
|5.||Belch, Andrew R: 6 articles (01/2014 - 03/2005)|
|6.||Adamia, Sophia: 5 articles (01/2014 - 03/2005)|
|7.||Pasonen-Seppänen, Sanna: 4 articles (09/2015 - 07/2009)|
|8.||Mant, Michael J: 4 articles (01/2014 - 03/2005)|
|9.||Brown, Tracey J: 4 articles (04/2010 - 07/2005)|
|10.||Sasaki, Mutsuo: 4 articles (07/2006 - 09/2004)|
|1.||Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
09/01/2006 - "We previously showed that (1) CD44 regulate keratinocyte proliferation; (2) topical retinoids dramatically increase the expression of CD44, hyaluronate and hyaluronate synthase (HAS)s in mouse epidermis; (3) topical retinaldehyde restores the epidermal thickness and CD44 expression which are correlated with clinical improvement in lichen sclerosus et atrophicus lesions; and (4) retinaldehyde-induced proliferative response of keratinocytes is a CD44-dependent phenomenon and requires the presence of HB-EGF, erbB1 and matrix metalloproteinases. "
09/01/2014 - "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance."
08/01/2014 - "Both normal and abnormal TGFβ signaling can be detected in carcinoma and stromal cells, and TGFβ-induced EMT requires the expression of hyaluronan synthase 2 (HAS2). "
04/26/1996 - "HAS-, a mouse mammary carcinoma mutant cell line, which is defective in hyaluronan synthase activity, was first established and used as a recipient for the expression cloning. "
09/19/2014 - "Our previous studies using a hyaluronan synthase 2 (Has2) transgenic mouse model demonstrated that hyaluronan overproduction caused rapid development of aggressive breast carcinoma at a high incidence. "
04/01/2013 - "HA is primarily synthesized by hyaluronan synthases, and the current study investigated the role of hyaluronan synthase 2 (HAS 2) in oral cavity carcinoma progression behaviors. "
|3.||Melanoma (Melanoma, Malignant)
09/10/2015 - "In this study we produced a MV3 melanoma cell line with inducible expression of the hyaluronan synthase 3 (HAS3) and studied its effect on the behavior of the melanoma cells. "
09/10/2015 - "Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion."
12/01/1999 - "In this study we show that a human melanoma cell line stably transfected with hyaluronate synthase cDNA displays enhanced motility. "
09/03/2004 - "Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion."
12/01/1999 - "Next, in order to directly investigate the effects of hyaluronate on melanoma cell migration, we transfected cDNA encoding mouse hyaluronate synthase HAS1 or HAS2 into the re-cloned human melanoma cell line that produced a low amount of hyaluronate (WM793L) by the lipofection method. "
05/01/2015 - "Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance."
01/01/2014 - "Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression."
12/01/2013 - "Further, the use of 4-MU (a hyaluronan synthase inhibitor) on HepR21 cells reduces the HA level and downregulates the expression of growth promoting factors like pAKT and PKC; while upregulating the expression of the tumor suppressor p53. "
07/10/2009 - "We have identified a family of aberrant splice variants of HAS1 (the hyaluronan synthase 1 gene) in some B lineage cancers, characterized by exon skipping and/or partial intron retention events that occur either together or independently in different variants, apparently due to accumulation of inherited and acquired mutations. "
07/13/2007 - "Aggressive prostate tumor cells express 20-fold higher levels of the hyaluronan synthase HAS3, but the mechanistic relevance of this correlation has not been determined. "
01/01/2007 - "Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy."
09/01/2005 - "As for the posterior disc attachment specimens, patients with chronic closed lock showed a tendency for higher expression of biglycan and hyaluronan synthase 1. The degradation of matrix in patients with chronic closed lock of the temporomandibular joint seems not to be caused by a reduced synthesis and the degenerative process seen in these patients is one with low turnover similar to the situation in primary osteoarthrosis of hyaline cartilage. "
06/03/2011 - "Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension, osteoarthritis, asthma, thyroid dysfunction, and large organ fibrosis. "
01/01/2004 - "This study compares the regulation of three isoforms of hyaluronan synthase (HAS1, HAS2, and HAS3) transcripts and hyaluronan (HA) production by cytokines in human synovial fibroblastic cells derived from tissue from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). "
01/01/2004 - "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction."
|4.||heparin-binding EGF-like growth factor (HB-EGF)
|5.||Hyaluronic Acid (Hyaluronan)
|8.||Protein Isoforms (Isoforms)
|10.||Complementary DNA (cDNA)
|2.||Drug Therapy (Chemotherapy)