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hyaluronan synthase

highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA; do not confuse with HasA protein; Reaction: UDP-N-acetyl-D-glucosamine + n UDP-D-glucuronate = [b-N-acetyl-D-glucosaminyl(1 4)b-D-glucuronosyl(1 3)]n+ 2n UDP
Also Known As:
hasA enzyme; hyaluronan synthase 1; hyaluronan synthetase; hyaluronate synthase; hyaluronate synthetase; hyaluronic acid synthetase
Networked: 114 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Itano, Naoki: 9 articles (09/2014 - 01/2004)
2. Kimata, Koji: 8 articles (01/2011 - 01/2004)
3. Pilarski, Linda M: 7 articles (01/2014 - 03/2005)
4. Heldin, Paraskevi: 6 articles (08/2014 - 11/2002)
5. Belch, Andrew R: 6 articles (01/2014 - 03/2005)
6. Adamia, Sophia: 5 articles (01/2014 - 03/2005)
7. Pasonen-Seppänen, Sanna: 4 articles (09/2015 - 07/2009)
8. Mant, Michael J: 4 articles (01/2014 - 03/2005)
9. Brown, Tracey J: 4 articles (04/2010 - 07/2005)
10. Sasaki, Mutsuo: 4 articles (07/2006 - 09/2004)

Related Diseases

1. Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
2. Carcinoma (Carcinomatosis)
3. Melanoma (Melanoma, Malignant)
4. Neoplasms (Cancer)
5. Osteoarthritis

Related Drugs and Biologics

1. Matrix Metalloproteinases
2. Retinoids
3. Retinaldehyde (Retinal)
4. heparin-binding EGF-like growth factor (HB-EGF)
5. Hyaluronic Acid (Hyaluronan)
6. Hyaluronoglucosaminidase (Hyaluronidase)
7. 4-methylumbelliferone
8. Protein Isoforms (Isoforms)
9. Cytokines
10. Complementary DNA (cDNA)

Related Therapies and Procedures

1. Subcutaneous Injections
2. Drug Therapy (Chemotherapy)