|1.||Hamamoto, Ryuji: 7 articles (10/2015 - 08/2004)|
|2.||Nakamura, Yusuke: 7 articles (10/2015 - 08/2004)|
|3.||Meyerson, Matthew: 6 articles (08/2012 - 02/2004)|
|4.||Cleary, Michael L: 6 articles (07/2010 - 08/2003)|
|5.||Gascoyne, Randy D: 5 articles (10/2015 - 02/2010)|
|6.||Marquez, Victor E: 5 articles (05/2014 - 02/2011)|
|7.||Rozenblatt-Rosen, Orit: 5 articles (07/2011 - 02/2004)|
|8.||Hess, Jay L: 5 articles (01/2009 - 02/2004)|
|9.||Arrowsmith, Cheryl H: 4 articles (12/2015 - 02/2011)|
|10.||Davidovich, Chen: 4 articles (12/2015 - 11/2013)|
08/08/2013 - "Genetic and small molecule inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the development and maintenance of MLL-rearranged leukemia in model systems. "
12/23/2015 - "The histone methyltransferase MLL1 has been linked to translocation-associated gene fusion in childhood leukemias and is an attractive drug target. "
10/23/2015 - "Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex."
08/01/2015 - "We show that C/EBPα p30, but not the normal p42 isoform, preferentially interacts with Wdr5, a key component of SET/MLL (SET-domain/mixed-lineage leukemia) histone-methyltransferase complexes. "
01/01/2015 - "The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia."
11/04/2008 - "In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L."
12/01/2009 - "To study the role of miR-155 in these tumors, we identified JARID2/Jumonji, a cell cycle regulator and part of a histone methyltransferase complex, as a target of miR-155. "
12/01/2015 - "Notably, we demonstrate that SWI/SNF-mutant cancer cells are primarily dependent on a non-catalytic role of EZH2 in the stabilization of the PRC2 complex, and that they are only partially dependent on EZH2 histone methyltransferase activity. "
12/01/2015 - "Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. "
10/15/2015 - "SET and MYND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in cell growth and cancer pathogenesis. "
|3.||Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
|4.||Breast Neoplasms (Breast Cancer)
07/01/2014 - "This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, RORγ, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. "
07/30/2010 - "In this study we examined in human breast cancer cells the NSD3L isoform which contains the catalytic histone methyltransferase SET-domain. "
01/01/2015 - "Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells."
03/01/2014 - "Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells."
07/05/2013 - "microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8."
|5.||Neoplasm Metastasis (Metastasis)
08/01/2014 - "Histone methyltransferase G9a and metastasis-associated protein 2 were downregulated. "
07/02/2004 - "Recent studies have revealed the intrinsic histone methyltransferase (HMTase) activity of the EED-EZH2 complex and its role in Hox gene silencing, X inactivation, and cancer metastasis. "
01/01/2016 - "Moreover, Sox4 induces the transcription of Ezh2 which is the histone methyltransferase, and reprograms the cancer epigenome to promote EMT and metastasis. "
12/01/2015 - "Emerging evidence suggests that G9a, a histone methyltransferase, is involved in tumor progression and metastasis. "
08/01/2015 - "Enhancer of zeste homolog 2 (EZH2), a polycomb histone methyltransferase, is a key epigenetic modifier implicated in various cancer metastasis. "
|1.||Histone Deacetylase Inhibitors
|2.||Cell Adhesion Molecules
|4.||trichostatin A (A 300)
|10.||Histone Acetyltransferases (Histone Acetyltransferase)
|2.||Drug Therapy (Chemotherapy)