stigmastanol

saturated analog of beta-sitosterol; RN given refers to (3beta,5alpha)-isomer

Also Known As:

24 alpha-ethyl-5 alpha-cholestan-3 beta-ol; 24 alpha-ethyl-5 beta-cholestan-3 alpha-ol; beta-sitostanol; dihydrositosterol; sitostanol; stigmastanol, (3beta,5beta,24S)-isomer; (3 beta,5 alpha)-stigmastan- 3-ol

Networked: 35 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lütjohann, Dieter: 3 articles (10/2018 - 01/2012)
2.	Mensink, Ronald P: 3 articles (10/2018 - 01/2012)
3.	Plat, Jogchum: 3 articles (10/2018 - 01/2012)
4.	Shiri-Sverdlov, Ronit: 2 articles (10/2018 - 01/2014)
5.	Vreugdenhil, Anita C E: 2 articles (10/2018 - 01/2014)
6.	Jiang, Lu: 1 article (01/2019)
7.	Li, Chujun: 1 article (01/2019)
8.	Wang, Wei: 1 article (01/2019)
9.	Xu, Jun: 1 article (01/2019)
10.	Yu, Yue: 1 article (01/2019)

Related Diseases

1.	Hypercholesterolemia 09/01/1986 - "These results suggest that low-dose sitostanol might be a useful hypolipidemic agent for the treatment of mild hypercholesterolemia." 09/01/1986 - "Sitostanol (24-ethyl-5 alpha-cholestan-3 beta-ol), a hydrogenated derivative of sitosterol, was administered in a low dose (1.5 g/day) for 4 weeks to 6 patients with hypercholesterolemia. " 09/01/1986 - "Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia." 02/01/1995 - "Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia." 01/01/1994 - "Two plant sterols, sitosterol and sitostanol, have been tested in prepubertal and adolescent children with hypercholesterolemia and appear promising. "
2.	Inflammation (Inflammations) 01/01/2018 - "Furthermore, liver sitostanol to cholesterol ratio correlated positively with histological steatosis and lobular inflammation (rs > 0.407, P<0.01 for both). " 01/01/2014 - "In vitro, in isolated LPS stimulated bone marrow derived macrophages desmosterol activated cholesterol efflux whereas sitostanol reduced inflammation. " 01/01/2018 - ": Our study showed that liver and bile sitostanol ratios to cholesterol associated positively and liver sitosterol ratio to cholesterol associated negatively with liver steatosis and inflammation in obese individuals with NAFLD.." 01/01/2018 - "The mRNA expression of genes regulating liver sterol metabolism and inflammation was measured (n=102).Results: Liver and bile sitostanol ratios to cholesterol were higher in those with NAFLD compared to those with histologically normal liver (all P<0.022). " 03/05/2008 - "A mixture of beta-sitosterol, stigmasterol, stigmastenol, stigmastanol and campesterol was isolated from the fraction CD4-N and beta-sitosterol-glycoside from the fraction CD5-N, reducing TPA-induced inflammation by 78.2 and 83.7% at 1mg/20 microL/ear, respectively. "
3.	Non-alcoholic Fatty Liver Disease 10/31/2018 - "Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD." 01/01/2018 - "Therefore, we investigated the association between serum, liver and bile plant sterols and sitostanol with NAFLD.Methods" 01/01/2018 - "Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD." 01/01/2018 - ": Our study showed that liver and bile sitostanol ratios to cholesterol associated positively and liver sitosterol ratio to cholesterol associated negatively with liver steatosis and inflammation in obese individuals with NAFLD.." 01/01/2018 - "The mRNA expression of genes regulating liver sterol metabolism and inflammation was measured (n=102).Results: Liver and bile sitostanol ratios to cholesterol were higher in those with NAFLD compared to those with histologically normal liver (all P<0.022). "
4.	Neoplasms (Cancer) 01/01/2019 - "We performed a literature search of PUBMED, EMBASE, CNKI, and Wanfang, and studies published before May 2019 focusing on dietary total phytosterols, β-sitosterol, campesterol, stigmasterol, β-sitostanol, and campestanol, as well as their relationships with cancer risk, were included in this meta-analysis. " 09/01/2014 - "Conversely, cancer association was inverse with acetaminophen metabolites (OR <0.1), tocopherols (OR = 0.3), sitostanol (OR = 0.2), 3-dehydrocarnitine (OR = 0.4), pterin (OR = 0.3), conjugated-linoleate-18-2N7 (OR = 0.2), N-2-furoyl-glycine (OR = 0.3) and p-aminobenzoate (PABA, OR = 0.2). "
5.	Fistula 10/02/1985 - "This study aimed at clarifying the pathway(s) for the formation of 5 alpha-sitostanol, by use of rats with bile fistula. " 10/02/1985 - "Intestinal microorganisms are not essential for the above conversions, since the 5 alpha-sitostanol was found in bile from bile fistula rats. " 10/02/1985 - "The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula."

Related Drugs and Biologics

1.	Cholesterol
2.	Esters
3.	Margarine
4.	LDL Cholesterol
5.	gamma-sitosterol (beta-sitosterol)
6.	Phytosterols (Plant Sterols)
7.	campesterol
8.	campestanol
9.	Stigmasterol
10.	Dietary Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration