|1.||Kisiel, Walter: 11 articles (05/2008 - 01/2002)|
|2.||Ma, Duan: 8 articles (10/2015 - 02/2004)|
|3.||Honkanen, Richard E: 7 articles (11/2011 - 03/2003)|
|4.||Rao, Jasti S: 6 articles (06/2007 - 01/2002)|
|5.||Gujrati, Meena: 6 articles (06/2007 - 01/2002)|
|6.||Dinh, Dzung H: 6 articles (06/2007 - 01/2002)|
|7.||Konduri, S D: 6 articles (10/2001 - 01/2000)|
|8.||Rao, J S: 6 articles (10/2001 - 01/2000)|
|9.||Reverdiau, Pascale: 5 articles (01/2013 - 07/2003)|
|10.||Iochmann, Sophie: 5 articles (01/2013 - 07/2003)|
05/15/1998 - "In addition, since the inhibition of PP5 gene expression has marked antiproliferative activity and the overexpression of p21(WAF1/Cip1) blocks the growth of tumor cells, these studies suggest that compounds that inhibit of PP5 gene expression may be useful in the treatment of human cancers."
01/15/2012 - "The results of the present study revealed that TFPI-2 interacts with PSAP, which may play an important role in the physiology and pathology of diseases such as cancer."
09/01/2010 - "Earlier studies have shown that the production of TFPI-2 is downregulated during the progression of various tumors. "
01/01/2007 - "Our studies reveal the existence of a novel, aberrantly-spliced TFPI-2 transcript predominantly expressed in tumor cells and provides suggestive evidence for an additional mechanism for tumor cells to down-regulate TFPI-2 protein expression enhancing their ability to degrade the extracellular matrix."
07/01/2006 - "Previous studies have shown high expression of TFPI-2 by benign tumors and low or absent expression in highly malignant tumors. "
|3.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/01/2013 - "TFPI-2 may be one molecular marker for effective treatment of advanced non-small cell lung cancer with 5-Aza-CdR."
01/01/2015 - "Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma."
04/01/2012 - "TFPI-2 methylation predicts poor prognosis in non-small cell lung cancer."
01/01/2013 - "The present study employed 5-aza-2'-deoxycytidine (5-Aza-CdR) to treat non-small cell lung cancer (NSCLC) cell line A549 to investigate the effects on proliferation and expression of the TFPI-2 gene. "
02/01/2011 - "We showed in this study that stable TFPI-2 down-regulation in the National Cancer Institute (NCI)-H460 non-small cell lung cancer cell line using specific micro interfering micro-interfering RNA promoted tumour progression in a nude mice orthotopic model that resulted in an increase in cell invasion. "
10/18/2001 - "This is the first study to demonstrate that down- or upregulation of TFPI-2 plays a significant role in the invasive behavior of human gliomas."
07/01/2015 - "Moreover, knockdown of PP5 markedly suppressed glioma cell migration, as determined by Transwell assay. "
07/01/2015 - "Herein, the relationship between PP5 expression and glioma cell growth was investigated, and the therapeutic value of PP5 in glioma was further evaluated. "
07/01/2015 - "However, the role of PP5 in human gliomas remains unclear. "
06/15/2011 - "Lentiviral knockdown of TFPI-2 in two of the TFPI-2-expressing cell lines (MZ-18 and Hs 638) was associated with pronounced changes in the cellular behavior: glioma cell proliferation, migration and invasion were significantly increased in TFPI-2 knockdown cells in comparison to empty vector-transfected control cells. "
|5.||Lung Neoplasms (Lung Cancer)
01/01/2009 - "In conclusion, this study confirms that TFPI-2 downregulation can contribute to tumour invasion of lung cancer cells."
01/01/2013 - "In this study, low levels of TFPI-2 expression were found in 65% of patients with small cell lung cancer (SCLC), the most aggressive type of lung cancer. "
02/28/2005 - "Downregulation of TFPI-2 could thus enhance the invasive potential of neoplastic cells in several cancers, including lung cancer. "
01/01/2000 - "These data suggest that TFPI-2 is critical for the invasion and metastasis of lung cancer and that the downregulation of TFPI-2 production may be a feasible approach to increase invasiveness and metastasis."
01/01/2015 - "The in vitro induction of TFPI-2 in lung cancer cell lines decreased the expression of TMPRSS4 mRNA levels. "
|3.||tissue-factor-pathway inhibitor 2 (PP5)
|4.||Serine Proteases (Serine Protease)
|5.||DNA (Deoxyribonucleic Acid)
|6.||RNA (Ribonucleic Acid)
|7.||Messenger RNA (mRNA)
|8.||Proteins (Proteins, Gene)
|9.||Thromboplastin (Tissue Factor)
|10.||Placental Lactogen (Human Placental Lactogen)
|1.||Heterologous Transplantation (Xenotransplantation)