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WR 159412

Also Known As:

2,4-diamino-6-(5-trifluoromethylphenyl)thioquinazoline; WR 159,412; WR-159,412; WR-159412; 6-((3-(trifluoromethyl)phenyl)thio)-2,4-quinazolinediamine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - WR 159412: 1

Related Diseases

1.

09/01/1979 - "Application of these combinations prevented emergence of parasites resistant to WR-158,122 or WR-159,412, but did not abolish the differences in effectiveness of either compound against infections with pyrimethamine-susceptible and pyrimethamine-resistant strains; however, activities against infections with either susceptible or resistant strains were enhanced markedly. "
09/01/1979 - "WR-158,122 and WR-159,412, against Plasmodium falciparum and Plasmodium vivax infections in owl monkeys, were seriously impaired when infecting strains were pyrimethamine-resistant; and 2) that primary treatment failure with either agent led frequently to emergence of parasites resistant to these derivatives. "
09/01/1979 - "III. The capacity of sulfadiazine to enhance the activities of WR-158,122 and WR-159,412 against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys."

Related Drugs and Biologics

1.	Sulfadiazine (Sulphadiazine)
2.	Pyrimethamine (Daraprim)
3.	WR 158122