azoreductase

03/18/2019 - "In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for highly selective monitoring of lysosomal azoreductase under hypoxia in living cells. "
03/18/2019 - "Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes."
01/01/2019 - "Azoreductase-Responsive Nanoprobe for Hypoxia-Induced Mitophagy Imaging."
01/01/2019 - "Based on this, we report an azoreductase-responsive nanoprobe (termed Micelle@Mito-rHP@TATp, MCM@TATp) by encapsulating cationic spiropyrane derivative (Mito-rHP) to realize specific imaging of mitophagy in living cells under hypoxia. "
01/01/2018 - "It is worth noting that the employment of azobenzene moiety labeled on the DSDHC first ensured the aptameric nanosensor could be conjugated to the surface of AuNPs and then specifically reduced by hypoxia-related azoreductase. "

12/01/1995 - "In the present study, the azoreductase activity in feces of 14 patients with active Crohn's disease was decreased (11.39 +/- 7.93 mU/g F) as compared with 12 healthy subjects (51.13 +/- 21.39 mU/g F). "

05/01/1992 - "Because of the potential significance of colonic bacteria and secondary bile acids in the pathogenesis of colon cancer, the present study investigated the effect of different types of dietary fiber on fecal bacterial enzymes, namely, beta-glucuronidase, 7 alpha-dehydroxylase, nitroreductase, and azoreductase, and on bile acids and neutral sterols in premenopausal women. "

06/13/2023 - "Herein, we report an azoreductase activatable, endonuclease-gated fluorescent nanodevice for spatiotemporal amplification imaging of microRNA-21 in hypoxic tumor cells. "
06/13/2023 - "An azoreductase activatable, endonuclease-gated nanodevice for spatiotemporal amplification imaging of microRNA-21 in hypoxic tumor cells."
01/01/2022 - "The anticancer drug, curcumin, was encapsulated inside NI-Azo vesicles that successfully killed B16F10 cells (cancer cells) in CoCl2-induced hypoxic environment owing to the azoreductase-responsive release of drug. "
10/01/2016 - "A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells."
12/01/2021 - "Furthermore, azoreductase in the tumor site can break the -NN- bonds of AZO in Q-P-A@CP[5]A, leading to the morphology recovery of supramolecular nanoparticles and CRC therapy through inducing cell membrane rupture. "

10/01/1990 - "Fecal concentrations of nitroreductase, azoreductase, and beta-glucuronidase, which may be implicated in colonic carcinogenesis, were also assessed. "
12/01/1977 - "While the detoxifying azoreductase activity was not affected by portal diversion, the activating pathway leading to the binding of 4-dimethylaminoazobenzene metabolites to DNA, a major step for cell carcinogenesis that is mediated by microsomal enzymes, was decreased in shunted rats to about 50 percent of control values. "
01/01/2022 - "Gut microbiota can influence the development and progression of CRC, through influencing factors such as secretion of toxins; enzymes for activating carcinogenesis (including β-glucuronidase, β-glucosidase, azoreductase, nitroreductase, and alcohol dehydrogenase); hydrogen sulfide generation; generation of reactive oxygen species and inflammation; secondary bile salt transformation; and products of protein fermentation. "