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Met-enkephalinamide

Also Known As:

enkephalinamide-Met-; methionine enkephalinamide; L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Enkephalins: 1042
        Methionine Enkephalin: 610
        Met-enkephalinamide: 11
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Enkephalins: 1042
        Methionine Enkephalin: 610
        Met-enkephalinamide: 11

Related Diseases

1.	Neoplasms (Cancer) 01/01/1989 - "Antitumor activity of enkephalin analogues in inhibiting PYB6 tumor growth in mice and immunological effects of methionine enkephalinamide." 01/01/1989 - "The present study had three aims: first, to compare the antitumor activity of the synthetic peptide, D-[Ala2]methionine enkephalinamide (MEA), with endogenous enkephalins on PYB6 fibrosarcoma tumor growth; second, to determine whether tumor growth inhibition was mediated by an opiate receptor; and third, to investigate the effects of MEA on selected immune responses. "
2.	Fibrosarcoma 01/01/1989 - "The present study had three aims: first, to compare the antitumor activity of the synthetic peptide, D-[Ala2]methionine enkephalinamide (MEA), with endogenous enkephalins on PYB6 fibrosarcoma tumor growth; second, to determine whether tumor growth inhibition was mediated by an opiate receptor; and third, to investigate the effects of MEA on selected immune responses. "
3.	Bradycardia 11/16/1979 - "The site in the dog medulla oblongata where fentanyl or met-enkephalinamide produced vagal bradycardia was determined using microinjections. " 09/01/1984 - "Experiment 1 showed that intravenous administration of [D-Ala2]-methionine enkephalinamide resulted in dose-dependent inhibition of the tail-flick reflex, mild hypotension, and bradycardia. " 01/01/1980 - "4. High doses of morphine and [D-Ala2]-met-enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats. " 05/01/1988 - "Effects of intrathecal antagonists on the antinociception, hypotension, and bradycardia produced by intravenous administration of [D-Ala2]-methionine enkephalinamide (DALA) in the rat."
4.	Hypotension (Low Blood Pressure) 01/01/1980 - "5. High doses of [D-Ala2]-met-enkephalinamide produced only a pressor response in artificially-ventilated rats with no signs of secondary hypotension. " 09/01/1984 - "Experiment 1 showed that intravenous administration of [D-Ala2]-methionine enkephalinamide resulted in dose-dependent inhibition of the tail-flick reflex, mild hypotension, and bradycardia. " 01/01/1980 - "4. High doses of morphine and [D-Ala2]-met-enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats. " 05/01/1988 - "Effects of intrathecal antagonists on the antinociception, hypotension, and bradycardia produced by intravenous administration of [D-Ala2]-methionine enkephalinamide (DALA) in the rat."
5.	Seizures (Absence Seizure) 02/01/1983 - "MAO-B inhibitor deprenyl and beta-phenylethylamine potentiate [D-ALA2]-Met-enkephalinamide-induced seizures." 12/01/1986 - "In rats the influence of the delta opioid agonists [Leu]enkephalin, [D-Ala2-D-Leu5]enkephalin, [D-Ala2]methionine enkephalinamide and synthetic analogue of [Met]enkephalin: Tyr-D-Ala-Gly-Phe-D-Leu-OMe on audiogenic seizures was tested during ethanol abstinence. "

Related Drugs and Biologics

1.	Enkephalins
2.	Peptides (Polypeptides)
3.	Opioid Receptors (Opioid Receptor)
4.	Fentanyl (Sublimaze)
5.	Methionine Enkephalin
6.	Opioid Analgesics (Opioids)
7.	Selegiline (E250)
8.	T-Cell Antigen Receptors (T-Cell Receptor)
9.	Morphine (MS Contin)
10.	Monoamine Oxidase (MAO)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Injections
3.	Absorbable Gelatin Sponge
4.	Analgesia