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azelastine (Optivar)

azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia

Also Known As:

Optivar; Astelin; 4-((4-chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCl; 4-(p-chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone; A 5610; A-5610; ASTA Medica brand of azelastine hydrochloride; Afluon; Allergodil; Azeptin; Bayer brand of azelastine hydrochloride; Corifina; Dagra brand of azelastine hydrochloride; Loxin; Mann brand of azelastine hydrochloride; Muro brand of azelastine; Optilast; Orion brand of azelastine hydrochloride; Rhinolast; Sanfer brand of azelastine hydrochloride; Viatris brand of azelastine hydrochloride; Vividrin akut Azelastin; Wallace brand of azelastine hydrochloride; azelastine hydrochloride

Networked: 236 relevant articles (73 outcomes, 72 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 1
    - Phthalazines
      - azelastine: 236

Experts

1.	Sacks, Harry: 5 articles (11/2009 - 05/2005)
2.	Wheeler, William: 4 articles (11/2009 - 09/2007)
3.	Corren, Jonathan: 4 articles (09/2007 - 08/2004)
4.	Kaliner, Michael A: 3 articles (11/2009 - 04/2005)
5.	Berger, William: 3 articles (11/2009 - 05/2005)
6.	Wheeler, William J: 3 articles (09/2009 - 08/2004)
7.	Berger, William E: 3 articles (01/2009 - 08/2003)
8.	Petzold, U: 3 articles (01/2003 - 01/2000)
9.	Ellers-Lenz, B: 3 articles (01/2003 - 01/2000)
10.	Lieberman, P: 3 articles (07/2001 - 01/2001)

Related Diseases

1.	Rhinitis 07/01/1987 - "Azelastine, already proven effective in allergic rhinitis, has a bronchodilator effect at doses that do not produce intolerable side effects." 07/01/2000 - "RESULTS: The analysis of the Rhinitis Severity Score showed significant improvement only of rhinorrhea in the azelastine group (P = .03). " 03/01/1997 - "BACKGROUND: Azelastine is a topical antihistamine, clinically demonstrated to be effective in allergic rhinitis. " 02/01/1997 - "BACKGROUND: Azelastine is a selective H1-receptor antagonist, which has previously been demonstrated to be effective in the treatment of allergic rhinitis. " 01/01/1996 - "In conclusion, these results suggest that Allergodil is an effective treatment of the symptoms of allergic rhinitis in children. " Order ALL the reference details at left...
2.	Asthma (Bronchial Asthma) 05/01/1989 - "Azelastine was more effective in improving respiratory function (forced expiratory flow in 1 s and peak expiratory flow rate) when given in the once daily regimen, whereas clinical measures (number of weekly asthma attacks) were most improved by twice daily dosing. " 11/01/1997 - "RESULTS: Compared with the placebo-treated group, the azelastine-treated group exhibited significant improvement of asthma symptoms (p<0.01), PEF (p<0.01), PEF diurnal variation (p<0.001), excluding forced expiratory volume in 1 s or airway responsiveness. " 11/01/1990 - "Thus, azelastine was safely tolerated over one year and might be effective in intrinsic asthma." 11/01/1988 - "A study of the clinical efficacy of azelastine in patients with extrinsic asthma, and its effect on airway responsiveness." 03/01/1990 - "Evaluation of the safety and efficacy of multiple doses of azelastine to adult patients with bronchial asthma over time." Order ALL the reference details at left...
3.	Seasonal Allergic Rhinitis (Hay Fever) 04/01/1994 - "Azelastine nasal spray, administered either once or twice daily, was effective in treating the symptoms of seasonal allergic rhinitis and demonstrated a rapid onset of action with a duration of response lasting 12 to 24 hours." 06/01/1999 - "OBJECTIVE: Three multicenter, randomized, double-blind studies were conducted to determine whether patients with moderate-to-severe symptoms of seasonal allergic rhinitis who had responded inadequately to monotherapy with either an oral antihistamine or an intranasal corticosteroid, and who were candidates for combination therapy with both an oral antihistamine and an intranasal corticosteroid, could be effectively treated with azelastine nasal spray monotherapy. " 03/01/1987 - "In addition, azelastine has been shown to have an effect on the upper airways by effective symptom relief in patients with seasonal allergic rhinitis; furthermore, azelastine affords protection against exercise and allergen provocation." 07/01/1999 - "Azelastine hydrochloride is a nasally administered antihistamine that is effective and safe for the treatment of perennial and seasonal allergic rhinitis. " 04/01/1998 - "We have evaluated the efficacy of azelastine, a new long acting antihistamine, in the topic treatment of seasonal allergic rhinitis to Parietaria officinalis. " Order ALL the reference details at left...
4.	Pruritus (Itching) 04/01/2003 - "Both drugs were found to be equally effective in relieving itching [18 (58.1%) in the MMC group versus 18 (52.9%) in the azelastine group; not significant]. " 01/01/2003 - "RESULTS: Azelastine significantly improved itching and conjunctival redness compared to placebo (p < 0.001) with global tolerability that was not substantially different from placebo. " 01/01/2003 - "Azelastine significantly improved itching and conjunctival redness versus placebo (p < 0.001). " 02/01/1998 - "In all 230 evaluable patients with moderate to severe itching, azelastine caused an overall significant improvement in comparison to placebo (P = 0.02), with significance also for pruritus (P = 0.01 after 1 week and P = 0.02 after 2 weeks). " 01/01/2003 - "Itching and redness further improved at Day 42 (score improvement > or = 2 in 95% with azelastine versus 33% placebo) and completely resolved for 47% azelastine patients (versus 10% placebo). " Order ALL the reference details at left...
5.	Sneezing 01/01/2001 - "OBJECTIVE: Two multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trials were conducted to determine whether patients with symptoms of VMR (rhinorrhea, sneezing, postnasal drip, and nasal congestion) could be effectively treated with azelastine nasal spray. " 09/01/2006 - "Significant differences favoring azelastine nasal spray were seen for the individual symptoms of sneezing and nasal congestion. " 08/01/1993 - "In the first study, compared to placebo a one week's treatment with azelastine resulted in substantial relief of sneezing (p = 0.009), nasal itching (p = 0.009), swelling of the nasal mucosa (p = 0.067) and rhinorrhoea (p = 0.262) in patients having the above symptoms at baseline of at least moderate to severe intensity. " 01/01/2002 - "RESULTS: Compared with placebo, treatment with intranasal azelastine resulted in significant reductions in allergen-induced sneezing, rhinorrhea, itching, nasal congestion, and levels of albumin during the early-phase response (P <.05). " 12/01/1993 - "Analysis of this diary data showed significant reductions in sneezing, blocked nose, running nose, and itching nose during azelastine treatment. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	azelastine (Optivar)
2.	Beclomethasone (Beclometasone)
3.	Histamine (Histamine Dihydrochloride)
4.	Budesonide (Pulmicort)
5.	Chlorpheniramine (Chlorphenamine)
6.	Histamine Antagonists (Antihistamines)
7.	Terfenadine (Seldane)
8.	olopatadine (Patanol)
9.	Ophthalmic Solutions (Eye Drops)
10.	Tablets

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)
3.	Self Medication
4.	Intranasal Administration
5.	Activities of Daily Living (ADL)

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