brotizolam

10/01/2013 - "Brotizolam is effective and safe in relieving the symptoms of insomnia."
06/01/1985 - "Fifty-nine outpatients with insomnia were treated in a 3-week study to assess the safety and efficacy of a new triazolothienodiazepine with a short t1/2, brotizolam. "
10/01/2013 - "A randomized, double-blind, double-dummy, multicenter, controlled trial on brotizolam intervention in outpatients with insomnia."
01/01/1983 - "Brotizolam and chronic insomnia: a multi-centre study."
10/01/2013 - "To investigate the efficacy and safety of brotizolam in outpatients with insomnia. "

02/01/1986 - "In both trials, brotizolam produced significant increases in self-rated perceptions of sedation, fatigue, feeling 'spaced-out', and thinking slowed down. "
02/01/1986 - "Brotizolam produced self-rated perceptions of sedation and fatigue during 4-6 h after dosage, but objective impairment of psychomotor performance was minimal. "
01/01/1979 - "Heart rate and blood pressure exhibited no relevant changes, while side effects including fatigue, drowsiness and dizziness were mostly observed after the highest dosage of WE 941."

06/01/2006 - "On the sixth day they received a single oral 0.5-mg dose of brotizolam, and blood sampling was performed for 24 hours, together with an assessment of psychomotor function using the Digit Symbol Substitution Test and the Stanford Sleepiness Scale. "
06/01/2002 - "The study of polysomnography and sleepiness the morning after administration of triazolam and brotizolam."
06/01/2002 - "Using polysomnography, sleep effect was studied, then the sleep latency test (SLT), Stanford Sleepiness Scale (SSS), and Kwansei Gakuin Sleepiness Scale (KSS) were studied the next morning after administration of either an inactive placebo (PL), 0.125 mg triazolam (TL), 0.25 mg triazolam (TH), or 0.25 mg brotizolam (BR). "

01/01/2021 - "Anxiety, depression, and sleep disorders occur in about 15% of pregnant and lactating women; however, no studies have examined brotizolam transfer across the placenta or its excretion into breast milk. "

06/01/2012 - "The present study describes activity pattern changes after a single dose of brotizolam in elderly patients with dementia. "
06/01/2012 - "Use of brotizolam in elderly patients with dementia, especially in advanced stages, calls for closer attention and longer observation periods."
06/01/2012 - "Findings showed changes in activity levels and reversed active/resting phases after a single dose of brotizolam in elderly patients with dementia. "
06/01/2012 - "Around-the-clock movements of dementia patients who were administered a single dose of brotizolam were recorded by the integrated circuit tag monitoring system during a 4-week baseline and 7-day peri-administration period. "
06/01/2012 - "Changes in activity patterns after the oral administration of brotizolam in institutionalized elderly patients with dementia."